ID   A0A1I8FNZ2_9PLAT        Unreviewed;       355 AA.
AC   A0A1I8FNZ2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_41530-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_41530-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_41530-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8FNZ2; -.
DR   WBParaSite; maker-unitig_41530-snap-gene-0.2-mRNA-1; maker-unitig_41530-snap-gene-0.2-mRNA-1; maker-unitig_41530-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   InterPro; IPR027936; Eph_TM.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR46877; EPH RECEPTOR A5; 1.
DR   PANTHER; PTHR46877:SF14; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR   Pfam; PF14575; EphA2_TM; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        171..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          172..272
FT                   /note="Ephrin receptor transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF14575"
FT   DOMAIN          276..355
FT                   /note="Serine-threonine/tyrosine-protein kinase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF07714"
FT   BINDING         307
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   355 AA;  37536 MW;  EAA98FC2B8582B35 CRC64;
     SRQPLQKTPW CWRITLTELC SAGHAPEYTG GRNDTRYVVE CVDCGGARLV YEPASSLTDG
     GRSRKPSSIT VKIESSASVR VRVSWSSSDT WAAAAPPNTS SNSASNLTLQ RAPRTTPQLM
     NSSSELLRMG EFSDAVSINT LIPSRPENLG GTGATDSGAG NGAGNGANVN IIIGAVVAVL
     LCLVIVLTMI ILMSRRGHLL PFGRKLMTGD KASQGGANSG GAASSALDCN MLPYSNIPLG
     LHLPQHLKSY VDPHTYEDPS LALQEFAKEI DASWIAIESV LGGGEFGDVC KGLLTAPGRE
     PQPVAVKTLK PGASDKNKLD FLTEASIMGQ FDDPNSPNMI VTEYMANGSL DVFLR
//