ID A0A1I8FR20_9PLAT Unreviewed; 767 AA.
AC A0A1I8FR20;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=LisH domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_4318-snap-gene-0.1-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_4318-snap-gene-0.1-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-unitig_4318-snap-gene-0.1-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR AlphaFoldDB; A0A1I8FR20; -.
DR WBParaSite; maker-unitig_4318-snap-gene-0.1-mRNA-1; maker-unitig_4318-snap-gene-0.1-mRNA-1; maker-unitig_4318-snap-gene-0.1.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR006594; LisH.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS50896; LISH; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 44..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 87731 MW; CE7966735DAFB68E CRC64;
MASSVGCGLF VSSSSSRVVC SISEHLPVQQ QQQPTTAARS LIEPFRRGLL QQRRQKRNRT
SVMEPFRQTP QLPPPLRRRP RRRPRRRPAA FNVLPGASSA KRLGNSSIIS FCQHRGLFEA
VAAFLQQADD FDGNDEVSPG SWNLQESSEQ QQKQKSTMTR QKTEPSEFSS ETRKSFVFSS
HRLRTAKAFL DNSTFHGLWR VQPSANKQNL LSRKMHLLWT LIVIAAISCL WLHVYKQVSR
YFKYPLQSST REILNDFHFP SVTICEAWQM KFFKENYKSV SLRLANEPED YLNMTYWLFD
VPKSENTLQY LSNSTAYGLS VLDLLIDCKL NGLPCDKDSF SAFYHRQYGN CFTFDAEVHH
DEKLGHSGSR VHEGLSLILY SPSSDPYFRN FSDPVPLDSS GVSGLEIDGV LVTAHEANTV
PRVSEDSIIA ATSHETKIGL KEVRTTLVNT PARPCHESSN FRVHDHLVPI ERTYKTSLPD
RLEWEDIVQV LKSCNCLASS PVGVPTHLAN YSGVRQCADL FDALRGDFPK YRNFRNHECQ
EKFNRGKFSC REKLLKEFPA LARNWEEFQC YQRLTNQSFH ESDAQVLEAD DQCSSISYQF
QIFTSELPDS QSASWQFGRY DARLIFQTFS TILDRYLKRF ENSREDELPA VVRSVRSKGL
RPGECTTMID RKFKDEENCS DVQEFISRHF LRVQVYPFSL SVVHIAEERS YSIVDLFSHL
GGILGLWVGS SIVSLFELLE LVTFLSASSL SFSLNKRLQK SNSGLLC
//
