ID   A0A1I8FSZ9_9PLAT        Unreviewed;       765 AA.
AC   A0A1I8FSZ9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=G_PROTEIN_RECEP_F2_4 domain-containing protein {ECO:0000313|WBParaSite:maker-unitig_5295-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-unitig_5295-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-unitig_5295-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8FSZ9; -.
DR   WBParaSite; maker-unitig_5295-snap-gene-0.2-mRNA-1; maker-unitig_5295-snap-gene-0.2-mRNA-1; maker-unitig_5295-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   CDD; cd13952; 7tm_classB; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR12011:SF473; FI21270P1-RELATED; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        335..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        407..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        491..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        549..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        576..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          333..601
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   REGION          75..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          632..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          707..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        634..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..729
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   765 AA;  82884 MW;  8D5BE815B68E3E89 CRC64;
     ARLRCPSARR RRTVLNPLTG FCETLADLTG QECRQLAEPA AVSNRIALAP PGRSDLARLP
     AGRPGRMLSG FAKSQPFRDL GPGAPVRQPC CRPTAGRRQR LRALSAPDSL ADSRPPCWTL
     WPEFAAKACW PGPDAPESEA EFPQPRRGGE LRAGPAWTTS GGALQFGTGR ASAPPPVSVQ
     RLRPDGTQLV RSADRSSTVK LRLLPDSAQG TAVSMVTTVL NLPHLTRRLG TAKQPVVSNV
     IQATYAASSG QPAAEVLLLI PHSRISGQLR HRCLLAPEFL SPSGCRVAVE LSSPTVTACL
     CRHLSSFAVT VLPGTAWLGV ETHRLWRLHS EPLRILTWIC LSVSIVCLLL TSITYIVVRM
     QTPMADKSIA TLHRVHRSLC LALMLGQALF LAAFQPLDAT PIAACKLLSV LTLYALLCAF
     CWLLCEGLMY THSLVKFWHY CLASGVAPLL IVLPTAALRP EQLIQTEADA SADSGGLLRP
     SVCWLSGDHG VSFAFIGPAM AVCLVNLCLF AVIMRRLAGT RSDAADAVGG SAATSASLRL
     SYLSRQMKVT ATLACLLGLT WLLGLMFLFA ETHLFIVAQY LFTLLNGLQG CFIFATQVCA
     HKRVREDWEK FLIDGRRTPG SLRRLLEQRR NARLSAPGSG STPANKAQQG RLRQPLLPRA
     GAAAAAADRR QQSSRRPQQL ESGFFDSRAF GDTRLDDQSL FDITHSQAEP ALRSPKSPLP
     EPPPIDTLPA RCPGSRELLY DVTDTQASSE YLVPDCKPTE QLTKV
//