ID   A0A1I8FVQ7_9PLAT        Unreviewed;      1289 AA.
AC   A0A1I8FVQ7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0000046-snap-gene-3.11-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0000046-snap-gene-3.11-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; maker-uti_cns_0000046-snap-gene-3.11-mRNA-1; maker-uti_cns_0000046-snap-gene-3.11-mRNA-1; maker-uti_cns_0000046-snap-gene-3.11.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.960.10; VSR Endonuclease; 1.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR   PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF03175; DNA_pol_B_2; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
FT   DOMAIN          573..753
FT                   /note="DNA-directed DNA polymerase family B
FT                   mitochondria/virus"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
FT   DOMAIN          894..1121
FT                   /note="DNA-directed DNA polymerase family B
FT                   mitochondria/virus"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
SQ   SEQUENCE   1289 AA;  144299 MW;  9C857134F3DDC4C6 CRC64;
     LKFEAGVNQP HISFVATCRN VPSWGFYNSP IFVAWGGAIK LLLLQAINQK FLTVVKFQAV
     RILVTMRIFI ADLAQFQPPP QPDTVEGDGF IARLGGAKAL PKFRAKGYEY EVSFTALTDI
     RATFEKVIAT LCADLNVDDF VASKLTADNM MLAINVPPVR RSRFTAELVF KHINKVLQSD
     SSVLGNNFKL FLLKAWVPRG GCGSLDAAER HIQARHSIGG RNYRQALSHS ALVVAKAFAD
     LQAKAITKQT WQTIKADSPM QKKLTGELQI AAKLPGLSGL MCSPTARGPE RPVARPDFGV
     RVYSAEEGNT CVYALPGREV LNLHLIGEHF NAVCKVPPFF GARRYCDRCQ QPYDCKSREH
     KCANTCPQCK VPGTDCKSLQ RDYKRCADCG LKCYNQQCFD NHRRKNRAGR SRCSSTRVCP
     NCGYCEDLKA GQKEPEHKCG HVKCPLCKQY DEAGSHLCFV KAPKVKASTM PYVFYDTETY
     TDDEKQHHVH LVTAVTCCET CSGRAFPRET CRLCNGLHSA ANCLTGRDLG EEFSNCVSHS
     DCACQMADFV SVGPASLNAF FAWLSTAFRG GAIVVAHNAS GYDSFLLLGA LLNGLAKKRP
     QVLFQGSRLM SMTVDKLVFK DSLNFIPIPL AQFPKALGLA DTKLAKGTFP HEFNKPANWN
     YVGSYPAIEY YGGKANKDYD SICAWLASRQ GELFNFNREY LDYCLSDTVL LREGCIKYRA
     IIGDICDGLE PFVQANTIAS LAMAVFTTRF MEPNSVGVIA RQADQQSFKA RKWLTYLNAT
     EFGGRLRTCD STDGEAVILG RKVDGFDEAS NTVLQFHGCF YHGCEQCMPD QDAVHPLKRQ
     PLSHIRHETE WFTRELERHN YSVRVIWEHE YDTVLASQAD FIAATAHLRA PLKMEDALYG
     GRVECFIPHA VASETETLKY RDVVSLYPTV QSKDPYPIGH PVQHPTPQVL DSDALASYFG
     IAKVTVLPPS NLHIPLLPYR VQKKLFFGLC RTCMEQQCGD DARALTGTWA TPELRKAFQL
     GYRLQVVHAL AYWTEKRTGL FSDYVSTFLK LKAESSGSPG MSDEDKAAYI ADFFAKEGVT
     LDKVEPNPGL RFVAKIFLNS LWGKFCQRDD LTSTEIVSSY EDWLARLTDP NLKVKACEPI
     GSEFMLLEYR HRYFNQRPFR VVYRHSEGQW EPPHGTSLGM WTDEVSAGSR MTDFVSGGPK
     LYTYIVEDAA GVRSQVLKCK GIRLTPEIRE RSDELRSALL HGGSLQLPQF QFRRDKASCT
     IHTVSMDKTF QRVLTKRVYG TCSRPYGYK
//