ID A0A1I8FXU1_9PLAT Unreviewed; 542 AA.
AC A0A1I8FXU1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=MAGUK p55 subfamily member 4 {ECO:0000313|WBParaSite:maker-uti_cns_0000306-snap-gene-0.4-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0000306-snap-gene-0.4-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0000306-snap-gene-0.4-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; A0A1I8FXU1; -.
DR WBParaSite; maker-uti_cns_0000306-snap-gene-0.4-mRNA-1; maker-uti_cns_0000306-snap-gene-0.4-mRNA-1; maker-uti_cns_0000306-snap-gene-0.4.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF42; MENAGE A TROIS, ISOFORM A; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..116
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 133..214
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 335..528
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 212..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 542 AA; 59347 MW; 32E2470984992DCC CRC64;
MLQLQQGICD SPLSMESLIK SGSLSSDDKE FLQQFSNDAN MNAVVKLCDI LEGYLARRVA
PVTPSALEDV VEAYDYLRCH PHAEGCHELV HLLRKPHMKA LIQCHDDLAN RTYGPRLSPV
PHEVDEDDVS VKIVELVKQD EPLGATIKIN ERTGAILIAR VMHGGLADRS DLLQAGDEVQ
AVNQVLVAGQ DPMTAIRMLT TARGNVRLSV LPSERRSSST AGGVGSVSSG GQQQVGVSPA
TVRVLFNYNP ADDGLIPCQE AGLCLRLGDI LQLLILLVTS LLSSMLSYFL LFVLSKKADS
SGSDQQQPPP QFYEELGRFY PGQPDGPTGS PVPPYRPLVL IGPSGVGRRE LARQLVGTDR
EHFALPVLVS TRSQQRPEPF VSLTAAQIRA LAEAGRLAEQ WTEDGGNETW ALPVDSLTKL
LRDGRVPVCV PHGPPPHCLL GLRTPSLRAF VVYVKPPPLD VLRETRAPHL LQQQDSLYDT
GRQLTLSELE AMVIEGQRME SACAHLIDFT LVNDDLPVAL ETLSELAYRL ETDFSYVPKH
WL
//
