ID A0A1I8G233_9PLAT Unreviewed; 131 AA.
AC A0A1I8G233;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Caveolin {ECO:0000256|RuleBase:RU000680};
GN ORFNames=BOX15_Mlig030848g1 {ECO:0000313|EMBL:PAA66047.1},
GN BOX15_Mlig030848g2 {ECO:0000313|EMBL:PAA87577.1}, BOX15_Mlig030848g3
GN {ECO:0000313|EMBL:PAA57186.1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0000659-snap-gene-1.13-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0000659-snap-gene-1.13-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0003268-snap-gene-0.6-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:PAA57186.1, ECO:0000313|Proteomes:UP000215902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DV1 {ECO:0000313|EMBL:PAA57186.1};
RC TISSUE=Whole organism {ECO:0000313|EMBL:PAA57186.1};
RA Berezikov E.;
RT "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT model organism for stem cell research.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes.
CC Interacts directly with G-protein alpha subunits and can functionally
CC regulate their activity. {ECO:0000256|RuleBase:RU000680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202,
CC ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004202, ECO:0000256|RuleBase:RU000680}. Golgi
CC apparatus membrane {ECO:0000256|RuleBase:RU000680}; Peripheral membrane
CC protein {ECO:0000256|RuleBase:RU000680}. Membrane, caveola
CC {ECO:0000256|RuleBase:RU000680}; Peripheral membrane protein
CC {ECO:0000256|RuleBase:RU000680}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the caveolin family.
CC {ECO:0000256|ARBA:ARBA00010988, ECO:0000256|RuleBase:RU000680}.
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DR EMBL; NIVC01002520; PAA57186.1; -; Genomic_DNA.
DR EMBL; NIVC01001595; PAA66047.1; -; Genomic_DNA.
DR EMBL; NIVC01000225; PAA87577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1I8G233; -.
DR STRING; 282301.A0A1I8G233; -.
DR WBParaSite; maker-uti_cns_0000659-snap-gene-1.13-mRNA-1; maker-uti_cns_0000659-snap-gene-1.13-mRNA-1; maker-uti_cns_0000659-snap-gene-1.13.
DR WBParaSite; maker-uti_cns_0003268-snap-gene-0.6-mRNA-1; maker-uti_cns_0003268-snap-gene-0.6-mRNA-1; maker-uti_cns_0003268-snap-gene-0.6.
DR Proteomes; UP000095280; Unplaced.
DR Proteomes; UP000215902; Unassembled WGS sequence.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070836; P:caveola assembly; IEA:InterPro.
DR InterPro; IPR001612; Caveolin.
DR PANTHER; PTHR10844; CAVEOLIN; 1.
DR PANTHER; PTHR10844:SF19; CAVEOLIN-2; 1.
DR Pfam; PF01146; Caveolin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU000680};
KW Golgi apparatus {ECO:0000256|RuleBase:RU000680};
KW Membrane {ECO:0000256|RuleBase:RU000680, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 131 AA; 14643 MW; 3C7B09E25DBEAB58 CRC64;
MTEIDLVNRD PNGINSGIQV KFEDVLAEPD GAHSMDCVWQ NSYKCYTCGL SLSYKIATLL
CGIFIALHWG CTFGCLAFNQ IWMITPKCKV FEIQMSCFRR FFTTILECCL GPCCATCGMF
FSNITVTNKS G
//
