ID A0A1I8G6T4_9PLAT Unreviewed; 371 AA.
AC A0A1I8G6T4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001035-snap-gene-1.22-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001035-snap-gene-1.22-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose
CC biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP
CC route): step 1/1. {ECO:0000256|ARBA:ARBA00004823}.
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000256|ARBA:ARBA00007274}.
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DR AlphaFoldDB; A0A1I8G6T4; -.
DR WBParaSite; maker-uti_cns_0001035-snap-gene-1.22-mRNA-1; maker-uti_cns_0001035-snap-gene-1.22-mRNA-1; maker-uti_cns_0001035-snap-gene-1.22.
DR UniPathway; UPA00126; UER00930.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:InterPro.
DR GO; GO:0009298; P:GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06425; M1P_guanylylT_B_like_N; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR045233; GMPPB_N.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22572:SF15; MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE BETA; 1.
DR PANTHER; PTHR22572; SUGAR-1-PHOSPHATE GUANYL TRANSFERASE; 1.
DR Pfam; PF00132; Hexapep; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..233
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 371 AA; 41136 MW; 54A5AF41961753F7 CRC64;
MKALILVGGF GTRLRPLTLS QPKPLVEFCN KPMMLHQVEA LAAVGVDHVI LAVSYRAELM
EQRLMKEGER LGVKFTFSFE EEPLGTAGPL KLAQKYLCQS ADPAEPFFVL NSDVICQFPF
QQMIEFHRAH GREGTIMVTK VEEPSKYGVV VYDEATGLID RFVEKPQEFV SNKINAGLYI
FSRSILDKIP NKPTSIEKET FPLMVQQGNL YALELHGFWM DVGQPKDFLT GMCMYIANSP
SACATPDGDA GKSADGGVGT AITSSLVHPT AKIGRNCRIG PNVVIGPNVV IEDGVRIRRS
TVLEGSKIRE HSWIDSCIIG WRCHIGRWVR MESVCVLGED VNVNDEIYLN GCRILPHKSI
GESQPEPQII M
//
