ID   A0A1I8G9E6_9PLAT        Unreviewed;       413 AA.
AC   A0A1I8G9E6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial {ECO:0000256|ARBA:ARBA00016714};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
DE   AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|ARBA:ARBA00031181};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001196-snap-gene-0.21-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001196-snap-gene-0.21-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC       catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC       isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC       hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254}.
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DR   AlphaFoldDB; A0A1I8G9E6; -.
DR   WBParaSite; maker-uti_cns_0001196-snap-gene-0.21-mRNA-1; maker-uti_cns_0001196-snap-gene-0.21-mRNA-1; maker-uti_cns_0001196-snap-gene-0.21.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT   DOMAIN          47..397
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   413 AA;  45287 MW;  39206599FB0DE0DB CRC64;
     MALCLLRKLP QLAARQHPGC LLPAMFCSTS SAGNDPDIVL SRRGCAGVIE LNRPKALNAL
     SLPMVRAMHP RLLDWEADPE VAVVLIKPAP GSGKAFCAGG DIRAIADDCV SARSAETGAG
     SGRAGGSLSR DFFREEYALN HAIGTYKKPY VAFIDGITMG GGVGLSVHGD YRVATERTVF
     AMPETNIGFF PDVGGGFFLP RLHAQIGVYL ALTGHRLSGE DVKKCGIASH FVNSEQLAEL
     EERLCGGEWL TKEGSFGTVS RLSELLQQFE ARSSLDMRVP FSLNRHMADI ERHFRHDTMP
     QVVASLSSDP SSWAAAQLET LRKMSPTSLR VTLRQLRLGM HLNLAGVLKM EYRISQRFMT
     NHDFVEGVRA ALVERRQPVW QPASVEEVSD EAVDEYFAPL PPDRELQLDT KRV
//