ID   A0A1I8G9Y8_9PLAT        Unreviewed;      1487 AA.
AC   A0A1I8G9Y8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=PLAT domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0001297-snap-gene-0.14-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001297-snap-gene-0.14-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001297-snap-gene-0.14-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   WBParaSite; maker-uti_cns_0001297-snap-gene-0.14-mRNA-1; maker-uti_cns_0001297-snap-gene-0.14-mRNA-1; maker-uti_cns_0001297-snap-gene-0.14.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd01752; PLAT_polycystin; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR002859; PKD/REJ-like.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR042060; PLAT_polycystin1.
DR   PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02010; REJ; 1.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        947..966
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1154..1175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1195..1217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1287..1309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1329..1353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1425..1444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          991..1108
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   REGION          1225..1250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1232..1247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1487 AA;  166146 MW;  BDCD8BA848510B48 CRC64;
     VNCYNNSVEV KWKIERYNNG TNSWQDFVPQ LKQFHQNYPS HVNYVSLDDT MISGVMYQGS
     NNQLKTFTVF PYAFNIHTVY RITVQATMVE EPALNTTDSI DVYIYKAPLR PCLNYRVYDQ
     ELSRWYKLSS PAQSKFGFEV EFDASCSVNP NKFALAGEFS DWDFEYYCNR ECEGELIFGP
     DASYSFANQP KNVCNKTNMN GDVVHNLTCI SNCHRSVIKN PKINGRACED EAININPNIP
     IKFQTSIDNY IPGVRFHYRW QISNLKKPVT SCPYDLSQSS VLAQLDMDEM GPDWSIIGIF
     SPGLAIDGVG CLPRASNGIY ILRVKSYRDG SPTNYGFKLL YLMINTAPDV SLLSVRAFPT
     VGEALNTRFQ LTCDGATDSD GSLKYNIGYS QLENPSGPDD CIPIEIGANE CKLSQATMLP
     SGAQKRDYMI TICIEVFDAA MASSFYNIST LLRVKERQMS IDELSNGNIY NRIEGSAYGG
     NSREMGKAAF PAINSLSTVT VDTPAQVQEM ILFKRKVVNL ISKCVNASDS NTTTDNRLRD
     LEFQSKMLST ITEGELDEDS LDVVAETAKN MAKNLLEISQ QRGVSYHEVL ASVNRLVTSS
     ESITSSLNNA EQNGAGNQDK SSNKLKLGNK QLGNYITAAD SLANKMVTDE RETHISTPNI
     SIVVVKRQPS KLNNAKLKAS GSTGCDNFKL GDFKDSYGSS LLVEPDPRNP NTTVPSQSAL
     TKLPLPATTM CSAPSNASDS SSGSEFRQEP CNCRNSTLGW FCSPLTDYNG TSVPAGPDYK
     LTNCMCNSTW CSPNSDLDST DNCEKSNSYQ PDLWTCYLSV DDLNTREVEK TVHFGIRAIK
     LDVDGKPSVK TIDGDSSSGN SENSKIPEYQ YLSMDFKSTA FTAGCYYFDT NSSQFSNIGV
     HVGQCSTPTE TQCFSSHMTS FMSSFYVPPL AFNPSDSGWL KLDSNPIALS VVLALVCFYL
     IIVVWVRRKD KDDMKKVGVT PLPDNHPADE FRYELTFWTG ARRHAGTTAQ VSFSLIGEDS
     ESEARPVLDP KRPVLQTGCV DSFFMTTPSY LGRLTHARIW HDNAGSDPKW YFNRLLVEDL
     QTGDKYFFIC NRWFAFDEDD GMVDRILPVS GMEEVRKFEV VFWSKAQKNL NDGHLWLSVV
     TRSPRSKFTR VQRATACLVL VMSTMMVNLM FYGQSKHVES PQLIEFGPIK LTAHSIYLAT
     VSSLIILPIN VLIVVLFKNR RNKPKKASKV KPRGPVTPDE ESGAGDGEKY AIGEPSVATE
     EAAGKSLKSK VLARIRPAVR RVWPLPWWSY IIGYILSFLS VAACTYLMVE FGGVLGEAKT
     SEWLASMLVT LLQSIVLIQP VKIVVIAAAY ALLVKKIDED EDEVTKEMVA AGLPPVHERL
     SIKDLTDPSK REMFLKSKRA PPPPDEHVLR ELREQRIREN NMNDILKDIV FYILFLVVLM
     MAAYTSQDYR SYLQNNYVKN MLTKGIYVQN ETHQAKTMSS AIRRDSL
//