ID A0A1I8GAM3_9PLAT Unreviewed; 4599 AA.
AC A0A1I8GAM3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=PHD-type domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0001237-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001237-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001237-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR WBParaSite; maker-uti_cns_0001237-snap-gene-0.3-mRNA-1; maker-uti_cns_0001237-snap-gene-0.3-mRNA-1; maker-uti_cns_0001237-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 1.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF56219; DNase I-like; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3210..3231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3251..3275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3287..3310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3316..3335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3390..3413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3893..3916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4169..4194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4224..4242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4320..4338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1114..1251
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 3488..3728
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2011..2044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4599 AA; 505405 MW; 73D8DACD3EE23CFA CRC64;
TPLRAPSPLA ATGAPGRQPG WKAGSGRAAR LLAAQLCQSQ KNINHSNNDT TTNSSSSSSS
SSSSRGQEGA LLENIMGSPE VQGETERPNL GTNCLPKQRC PAGGERLKHG SGDIDHDVRN
TDNIDTVLRL RGGKRSGSGK NGEDHSPELI LQFNCNGLRA RSTELAKWLQ TNRPAAILLQ
ETKLRTGQVF NPPDGYCVAA RCDGLPKDAA QRGQEPDERP SESSAPSDTC PTPWTRCGGR
RLTRPRCRMR WPEDRTEWCP GCKSGRTGCV RRNEPWPTPS LNQADITVIA TEDAGTHAPA
PTAAADAAGA TTITTQGASL APPKKTGWQC CKCGNQIKGR QYSVRCNGCN DWCHLSCSGL
GRSNRWTSAF KAEMCNSCTP VQPPPSQPPA ERSPSPSSPT PPSPIPIPTN KTRKNPINHA
ARGGAMILTR SDIAVDNIPT PGDKERGMLD VAAAAIHLKD SKPITLRVII GGDFNAHGIW
DSHQEEDDRG RRVEAWASAR NLRLANGERH TRTNPATGAL SSPDITWTST NLLSSVADSW
TTQSDMGSDH LPITFQLCSA HKRPTRQRRP RTAKWSYRKA DWSGFKQELA TIDAEREQYP
TEGVEAEHLH ALICDDILKA ASHNIPKGAL PRTKPFWSEE CEKATQACKE ARRTAETEPS
EPNIAAFKMA RNRVRSTIRK EKEKAWNEKA AQLDVNSDLF RLLKNMRGDG HTPASSTSIT
RHQTGGTAPS RPARTKLEKA NLFCQMYSAV SRVPKRPEDR LINKKAYEAA SARCCDADNR
QGICQPFNPT EYRNAVRALK SGKAPGQDGW CKEWKVELSV EKSVYGTFTL DAKESNGKKR
LNLLIDDKPI AFDPAPNYLG VRLDGQLNFA QHAATVRAKM CARRRPLAAM AGRSTGADLQ
TIRTAYISTV RAVAEYAAGT WLCGAAPSTR RAIEQQQNAC ARLITGCIMP TNIRSVLQLA
GLTPLSFIAS ERAARLRERV LRLDPSVSAG QVALRNTRPR LKNRTYEALA RDHGRTHGDG
GADDEAQPNS LNLIDPRDAT RPFRNCWRRA ALELPSVAIL DSHKRGDPVS PGIPPWECDT
RDINIRLDIS ARCRRTDPQE SRSAAATEFL QSLPEADISV WTDGSVADGT GPGGSAAITC
TNLASHVRKA PAGIICSSFD AEMIAIREAL VFIKNNCSPS EKKIRLCSDS LSSLTALGAG
PLAQATKTGT DCWRHMLDIN ETADIELIWV PAHCGISLNE AADRAAGMAR GLPQEEVPIS
FNAAKAAIRR DRRTLEKETL PQPWPDFKAR DRREQTAVCQ LRAGMTMLCA EIQHRFGMID
NPQCPDCGEL DDSAHALLHC HRGDARRMAL SGLVDAVVQH QTVVLEPLDA LKDGPEPHGL
LQLVLQHSRV VLAQHGVRKG RYERFVSSLQ LTFRVIDGSG GRGRGGCRLL RLRLTNAQED
APKESASSRV HAGSWLVQEH DGRVADERDA AGELALVASA VLLSGLVQRL TSQHLERGRL
ASSVDAQEAE ALLRLHSQTD AFDGGSRSGA GAENLDEPLQ FEQVGAGAGS VNLGSFSEHV
IVDLRCFRLP QRALVLGAVE EAEEARGHEA LLAAAVVLEQ QHERKVHNTV RHKAGQISAR
GAPGVVIRVE TFNIPAQVRG TCSSLFHQLR QSDIDLQEKQ ASMVNALLGT VITQLKGYIS
GALANPKRTM ERSDGLRTNE LIVLECHEQE DHNGQRHHVV QQVPDVVHDP VRSRVNSGHE
LQVLSVCGSL RDEEEHKAGG DEGQGEDNGH HCCSRRDGVS PAGHADLVRR ADALVSQSPH
DGVAEGVEVG RPGHVAPVVE PDLVHNGAQI SWQPDALKIR QNLSNEPRVP RKSVLFMCSI
SRLDRSMHSE LELIGSSLGV SSEAAPTTLS AALLQPSIAR CSCLRRTLSR RVGRKPTTEG
SSSSSSLFSK LQPADVCDER VNLLGDLRPA EAFEHAVEVD VVLHRQSVEK HIVLRTQAEL
LANLVHLCAD VVPADKGGAR SVTPFEAGFS WEDLDESDTG DDARDEAEAP RLSMPPSTST
LRNKAAQQVL RPSHTVREAV NHAVRHIAEE VDHAGEGGRH AREVKYLKSV GKEFLGLGLN
VRSNTLKFRV PSTDFCSYRS RYFVKLGVSL SNTNEAMNFG FVTPLFLPNS SIRNGSLSKP
YSLFMRKQAV EKYNLRIRES TVSRRSRQLP MLTEGGSMSG YGARNTDKLL QSRPYGVLPS
TLLHVVRAFC GVLRRDQDAE VNGRVAARRN SSGRHCGVTA GLVAHASAQR IGVLSEDSRP
AAAHQPAEAV DHIQQLGYAA AAAAAAAAAA AAAAAAAANQ SSQVSVDVAE DIQRAVLSNL
VELNQKMNER HKFYGNESNK RSTMLVTSDS STLIVCLLGK VEVIWNDRTA KAVWLHRAFT
SIQFLTPLLA PEHTRVGTAP ELSSAIDRVT RTDGLTDRSQ RCGTVAATPS NSWDELLLNN
EPRRIGLASA GLQSVAVLIK QRNAKNEDSN ADCLLLKALT ARVAPVGGQR GERSGDLPHG
WVGQRSVGEL QRLGQVPGAT ALEILAPLLS FLLLLIVRHS RDFRHASSAC QFKPAALASK
GPLAALRAFC HLGVCQQGDQ NFSSDAGLFN DTEFRNITQV LRAANLVLTN PTVRKFAKAV
MAVPAGANDT DMKLIQLSSV FGGATALLSG VDATEAQKKD FAKAEFRFPK RWHLSAGPVE
RLMLEPLMRM TETLPAVVCG SGGGGDDGWL TVATLCEQAK FRENLKSQFD MDAALDQMVS
TETNPHLIEL ELSDLTNLKT LLSGLKSLKL NGRLAALDEL WNLTASLAGG LGGNSDQATR
GILRLSRVLC GSGRSVFSKV AKRLRKQLQP LMSLPVEQFA SLKGSTHGND SARALHRKAR
DVGAAAAAAQ QSRRNDTKKL KQKNQEGQAA DLLEQFVPPE KFCLDRNSQS AIFGSLRYVL
PDIGLGSILK VMFGVIPFYP DTPRTRKFLE KLNRTLQGMS RLSYLAESFT QVFSPELEEF
VSKSNRMRLI RAALLACHGT LGSKSNGEMC LSLLKFLAPK PDPGGSFGSW RGLIKLTNSL
MRRLYYMTAC FRLNKLPGFG SLETLENYTR YLIDEFGQHS EAKKPLFIAS LLFDNQTSGF
VKYRLRFPED DVDDTRYFHV IDDKYTETSR TKFPTDFKYF TSFFLHIQEL LEQGIQAAIS
GVDAPIQTYM SMLPTACFID DKFISAMGSF LPMLMTVSWI YNVSLLVNAI VYEKETRLKE
MMKIMGLSDG VHWISWFITS LAIMSIASAL MTLLLSMGKI IIYSNPLLLF FFIVSFVVST
IFEAFFMSIF FSNSSVAAAF ARVIYFAGYL PFNLLETFGN SMTRTHYILS CLIPQLAFGV
GCKFISNWEL ASVGLQYDNF FDSPAANGEL SFGLVILMLW IDSAIFMLLT WYLEKVFPGE
FGVPKPWFFP FQPSFWCGKY SKPEKLTSCK SKVDKAQECI DHKQIINESP SPGLPLSDET
PKYLPVGIAI KNLTKIFSSR NWPCQKNAKT ISAVENLSYN FFEGQVTSFL GHNGAGKTTT
MSLLTGLYTP TSGTAFIGGY DIRTEMDQIR QQLGLCPQHN VLFDTLTVED HIYFYGMLKG
LSRAEVARQV DSFIADVGLQ KKKYEISKNL SGGMKRKLSV AMAFVGGSKV VVLDEPTAGV
DPHARRSIWD VLAKFRQGRT IILTTHHMDE ADILGDRICI INKGRLVCSG SPTFLKRVFG
EGYTLTLVKA SLECDTDKVL DLVQSKVPDA FLGDCTSSEI NVKLPYTSET KLASLFGNLE
KRMTDLKHIA TYGIEDSSLE EIFLSVTGWL ENTKLLRIPL LGWRNTESVL GSRGDSARMP
QALFKTSSIV QKYYIRWPIS SKSLVLAKTT RPMWQQIKAL WFKRFYVLRR SKIGFLAEFV
LPAVFILLTL ALLQIVPKDG DSPPMELAPW YMLGKPERSR LKDLSVFQSR SLTAYPNNHS
LTDLSNRLML HMNSTDFLGT RCMREDVFSN PDFPCKTQRR GSVWSETPSN LPSNTSWCQC
SYKDYPNSAK CVDWPTPARK SLMSSDIVES MQGYNLTNYI QSTVMEYYRK RFGGYTLFVN
DSQPVNADEQ SANVETQHVL RNLAKLTDDK STDCRAVRSI VNQVWYDNRC YLSGPAYLNT
LTNSIVRTLA NRSVGSADQI GNVLSANTMV SAMTVVSIIF ALSFIPASFV IFLISEKTTN
AKHLQFVSGI NPTMYWVVNH IWNLLNYIVP LTIVILLIFV AFKNYEFIGK ESLGPFLLTV
VLSGSPLGAD RSEQGVHHAS LPEPGHRVHD NNVRRDCHDA NLSNKGLDAY DKRWNASGRY
LACLVANSVV YFAFVLLLEY NCCCKQGLVM ITRCVQKETA EIDDDVRAEA AKRLVKIFST
SSGPRAAVKG ISLGVKSQEC FGFLGVNGAG KTTTFKMLTG ESLCAFEMRR LYAGPPRHRR
VGIEAHLDKT TQEYSGGNKR KLSCGIAFIG NPPIVFLDEP TAGMDPGARR FLWRCIQRMV
TAGSVHHLPA RSSAAVAGGD IRLCLGLRYV DNTEGQLERA HEAFMSAFPD AVLCENHAAV
LQYQLKQTVR LRTIFESVQR LKDNGLVLDY SVNQTTLDQ
//
