ID A0A1I8GG30_9PLAT Unreviewed; 431 AA.
AC A0A1I8GG30;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DNA_mis_repair domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0001741-snap-gene-0.14-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001741-snap-gene-0.14-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001741-snap-gene-0.14-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR AlphaFoldDB; A0A1I8GG30; -.
DR WBParaSite; maker-uti_cns_0001741-snap-gene-0.14-mRNA-1; maker-uti_cns_0001741-snap-gene-0.14-mRNA-1; maker-uti_cns_0001741-snap-gene-0.14.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF54; PMS1 PROTEIN HOMOLOG 1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763}.
FT DOMAIN 215..342
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 382..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 46233 MW; B81457C63573494D CRC64;
MSASQMRQLP AATARMLSSG QVILGPESVV KELIENALDA GATRVDVRLD SCGLDRLEVL
DNGRGFSASD ADLVAMRHCT SKLADDSGLA DLVTYGFRGE ALNSLCTVGQ LSMATRCQGE
ELGREYAFDK SGQVVSRRDV AMPTGTRVTV RQLFHCLPVR RQQLRSAKRL REALASVEAA
IRSAALANPG VRFALLSDGE ALLSLPECAS LNDRVRQVLS YAVWQQMQRL DCQINNAVGG
RVVAFVPASG ADKAMLFRNG DLHSFFIVNR RPVQSAKLVK MIRSTISSAF GVPTKLPVCV
LSIELPADAL DVNLNAAKTQ IGLANEAAVL ESIRTMLLDT VPNQSLATVS NTVATTADIV
VANNNNAPDS IVSNANNKDV RADAAGAAAE SHLPTSPVAP SAESPDQTEQ QQHQIRISTS
NTRSTRMRRK R
//
