ID   A0A1I8GGK9_9PLAT        Unreviewed;       323 AA.
AC   A0A1I8GGK9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:maker-uti_cns_0001957-snap-gene-0.5-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001957-snap-gene-0.5-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001957-snap-gene-0.5-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR   AlphaFoldDB; A0A1I8GGK9; -.
DR   WBParaSite; maker-uti_cns_0001957-snap-gene-0.5-mRNA-1; maker-uti_cns_0001957-snap-gene-0.5-mRNA-1; maker-uti_cns_0001957-snap-gene-0.5.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
SQ   SEQUENCE   323 AA;  37355 MW;  2AEA7DD08063EB94 CRC64;
     MLPEAARFFL ETTSIRGVGK IVKTQNVFLS RLWALFVLAS TSLLCYSVFK IIVDYLQYDV
     NIQTYHDIDD ATPFPAVSIC NNQAFSKNAY RLWADNRVRS PSEFNRQLRQ KALRMLSDPE
     FRAAYSSANQ SARQQLRESI QNRAYMSMHT SLVMDNSRTY YQNTAANDSI LLGHERNESL
     VECVKIIISR QALGTKGCHD PMLNVTLFSD PNFFNCMTIE FNEDSWSSEG FLYDVFEQAY
     GLRVAIHEPR TQPKILERGI QTEPGKMNEI KYQPVRFVRE NTPKKPCISP EETSHVKLRD
     LYNEYNYDQE LCLDSKVQAM VLE
//