ID A0A1I8GGV2_9PLAT Unreviewed; 627 AA.
AC A0A1I8GGV2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 22-FEB-2023, entry version 18.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0001913-snap-gene-0.6-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0001913-snap-gene-0.6-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR AlphaFoldDB; A0A1I8GGV2; -.
DR WBParaSite; maker-uti_cns_0001913-snap-gene-0.6-mRNA-1; maker-uti_cns_0001913-snap-gene-0.6-mRNA-1; maker-uti_cns_0001913-snap-gene-0.6.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18037; DEXSc_Pif1_like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF5; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044}.
FT REGION 165..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 67838 MW; 854DC30B9106EA8D CRC64;
DSEEAVAAGC SVACTATLER LDPRLGSVQH SRRITGCQLT LQRDSHGELR LRLAAKTHSA
NLSAKGVVIF KKFWREGKCT LRLPSESAQL LLSNCPVDRL ADFLKLLFVK QQCAASRQQR
AAPLRQLQQH RQPALPQAET DISPVSAADL AAVRARQAAA AAAAAGSAAS TATTPQRLQR
KRPAVAPAAS AAATAAMLQL PGFRPAGGTP PSLKGPRLDL LSSPLSAPGQ HALTEEQAAV
LDAVRSGVSV FYTGSAGTGK SVLLQRIVGM LPPDRTVVSA STGVAACQIG GQTLHSFAGV
GDGSGGIERC VSRAASRPAV AEAWRRCRHL VIDEISMVDA EFFDCLDVVA RTLRRSREPF
GGIQLVLCGD FLQLPPVKPS DAKGRRFAFE SSAWQRAVKA TLQLRQVHRQ ADRKFVDLLT
HIRYGRCEPR HSEMLRSTRR NLDESSANSD KDIVATQLCT HKRQVEAINQ HQLRLLPTES
VNFVAKDSMP AGLNSLLPSV PEKIELKIGA QRGSGPGWPV VRFVGGHERI VDQHEFAARV
AGAEMPVIRR QVPLQLAWAI SVHKSQGMTL DACRLYVSEA FEAGQVYVAL SRCRSLESLS
VANWDASCVR ADERVLNFYR QLRECSG
//
