ID A0A1I8GIT1_9PLAT Unreviewed; 518 AA.
AC A0A1I8GIT1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=isocitrate dehydrogenase (NADP(+)) {ECO:0000256|ARBA:ARBA00013013};
DE EC=1.1.1.42 {ECO:0000256|ARBA:ARBA00013013};
DE AltName: Full=NADP(+)-specific ICDH {ECO:0000256|ARBA:ARBA00029990};
DE AltName: Full=Oxalosuccinate decarboxylase {ECO:0000256|ARBA:ARBA00031098};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002033-snap-gene-0.8-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0002033-snap-gene-0.8-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR AlphaFoldDB; A0A1I8GIT1; -.
DR WBParaSite; maker-uti_cns_0002033-snap-gene-0.8-mRNA-1; maker-uti_cns_0002033-snap-gene-0.8-mRNA-1; maker-uti_cns_0002033-snap-gene-0.8.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR004790; Isocitrate_DH_NADP.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR NCBIfam; TIGR00127; nadp_idh_euk; 1.
DR PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT DOMAIN 7..398
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57667 MW; 211FA7D2D917C6AB CRC64;
MKIKGGAVVE IQGDEMTRII WDLIKEKLIL PFVDLDIHFF DLGIQNRDAT NDQVTVDCAY
AIMQHNVGIK CATITPDEQR VSEFGLKQMW RSPNGTIRNI LGGTVFREAI ICRNVPRLVP
GWSKSIVIGR HAFGDQYKAT DFVVPGPGKL EIKWTPDVPD QAPIQHQVFH FTNPGVALAM
YNTDASIKDF AHSSFRLALD KKWPLYLSTK NTILKKYDGR FKDIFQEVYQ AEYKAAYEAA
GIWYEHRLID DMVAYAMKSE GGFVWACKNY DGDVQSDSIA QGFGSLGLMT SVLVCPDGKT
IEAEAAHGTV TRHYRMHQRG EETSTNPIAS IFAWTRGLAH RAKLDSNAAL AHFCQTLERV
CIETIEAGHM TKDLALCVKG SGVQRSDYLN TFEFMDKLAE NLRAGLADTD VSRNSLAPLR
PLGAKPGSRG SFRELHRGVE LPREGGRDLR PGAMGPGPSA PEWKKISFRK TSFVDAEVRP
GKDRMAQLTD KGVPQTLDAV ELVRCGSPLT MFGSFEFN
//
