ID   A0A1I8GJH8_9PLAT        Unreviewed;       856 AA.
AC   A0A1I8GJH8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=DEP domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0002086-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002086-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0002086-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8GJH8; -.
DR   WBParaSite; maker-uti_cns_0002086-snap-gene-0.2-mRNA-1; maker-uti_cns_0002086-snap-gene-0.2-mRNA-1; maker-uti_cns_0002086-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR004776; Mem_transp_PIN-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR22829:SF5; INTEGRAL MEMBRANE PROTEIN GPR155; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF03547; Mem_trans; 1.
DR   SMART; SM00049; DEP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        304..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        411..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        614..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..675
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          748..803
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   REGION          487..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   856 AA;  94864 MW;  991D8618E01D152A CRC64;
     HPGRGWRRRH GPPVPAIVQC FVVILTGYAA CRTGLLPESQ AKGLGRFVST FALPSLIFRF
     MVTIDLSVNI LFPSITRYLY LFAPISFLII NPIGFIMIEI DRALSAASAG AAADDQLSGS
     EPGQLAANSD CAAVKESSQP ETNNRQRCLD VLGDIAKGVL LNPLVFMSAL GVIFNFICSR
     RLPEIVDSVL SIFGNAFSAT ALFYLGVNMV GKTAQLRSAP FVMRELVQSF RPGVYANDTL
     AYSTFAFLYG ALPPAPTVFV YTAQFSIASP APELVASGLV SSTFLCAPLM YISSRLISAA
     DYFISHTSIN VSLVSLACQL VTLAYLLLSR RAFRVPHLFL LSLLACHCVT CLAMVVSQAL
     PQDPSRHQLN LLQFVAFFFG VVGTRIWTAV LAVSMLLLRM RGLCYVLKYK AYFFFTGFGL
     TTFLAGIMLI STTNAGPVKD VDPAFQFGKR QYIFTTAVLV PCLVCTVASL VLHHRLSYQP
     RPGYESLPAS DEEADGLPAA STDNSFGDDS YAGEASGIGS PEFSVQFSDA PDAAIDSDEY
     SENGESGPME RHLQQQHAAY VSRRMCSQSV GCQSIEERAR CTRQLLNYRH RSPRLRREEI
     VTPDEEFLTA RYQLMLLLFT LSMLIGLFLL IWRIVNEEVS GVYIELEFLD SVFNYGQGVF
     ILGLLGWDYT VLPLLTRRID RLCRRLRMLM FNEDRIHLPP ESHLDQHVIS TRDNFLMHHM
     DHCLHSMRFS RRRLSVGKFG ANHQAGEFSG KALVDWLMSV GLCQDRIDAV AYGERLLLAR
     VLRHEQQAYH FRDSPDYRYV FSEEAENAAA AACPEAAAAA TAGDAVNRRC GRCVSLSSRD
     ARDIEDLVNA ETDHLH
//