ID   A0A1I8GLE9_9PLAT        Unreviewed;       948 AA.
AC   A0A1I8GLE9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=PBPe domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0002262-snap-gene-0.8-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002262-snap-gene-0.8-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0002262-snap-gene-0.8-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8GLE9; -.
DR   WBParaSite; maker-uti_cns_0002262-snap-gene-0.8-mRNA-1; maker-uti_cns_0002262-snap-gene-0.8-mRNA-1; maker-uti_cns_0002262-snap-gene-0.8.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   PANTHER; PTHR18966:SF422; KAINATE-TYPE IONOTROPIC GLUTAMATE RECEPTOR SUBUNIT 1D; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        137..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..306
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   REGION          544..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        547..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   948 AA;  101985 MW;  0216798416C5218B CRC64;
     MVGDVLRKEA DFAIGPFTMT AIRQTVIDFS VPFMQDGNAI LIKKPEQENP MFRVLSPFSL
     YSWLAILGSM LLSSFCIFVY SRLSPFSGWN LNLPDRITDE VSYKENLWSA IGTFLQQGEF
     GNFLCQDFFP VAASARIVLG LWWCTVVVIM ALYTADMIGY LTLNLPATSV ESLEQLAAQS
     VIEPAVKSGA NAYTLFEKSP AGSTYNNIFK LMGNMPKFTE TEQGVNLVKG ANFSDRQFAF
     IGDRTQLSYS ALTNCDLLLL SDIFNVATFG WPMQKDAPYK EDINRELQRL VDSGLMARWI
     KKWWSAENIC AIESDLSDAK PVDLLQAGGT FIILAGFFAA GAVVLLAECL LHQITLCCRR
     CRTGNIGRAG LDDCLGHARL HHGCGLAQGA AAGAEGGAAA STAGQQRQRL VAVGRPSRAA
     AGIGISNFAS VSAVSTAGAS AVSASAQTAG RQVLGQDGAH GGAERFVEKG VQDGISGAVD
     VGKQGGEVAG HGHPARRHVF ELQSDVDVDP VWQAAGQVEC DHGHNQDGDL LEALLRLGPG
     AASSLHQPEL AQDQKVEGAQ QQPGQHAAGD EDVPAEISPI VLMVRSCVFT RRWDDPSLDV
     GVEVDGADDQ SAQQPHADYK DDGEFLGAVA GRAERRYDGL ESVEAHRHDD VDAHVGVGER
     VGNGQVDQVN IRDGVGRLQR ADHDQYQQVA GEAEDKQRAK HGVVHRQSSW HSLTWLASYS
     RPPLSSKLNF SPGRAGGDGV WISSPFRVSL VAHQKRSPSC KEALPLSPST VAVADGPASE
     LYVREARRFI NVAGHRHGQR LLPAVHPAGQ VHQVHAEVAQ GSATMSFVVE ASKIRQRHAE
     VGLHESHGAQ LAVRHGLTQT RVGGKEAAPQ SHHEEAAGGL GQRQQLGCLL WQQSQRLLAQ
     HVLAGLEEVA RMLIVQIGQA ADVHHVCGIR ATVKWIGTTC AITSIKPV
//