ID   A0A1I8GMI7_9PLAT        Unreviewed;      1298 AA.
AC   A0A1I8GMI7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Guanylate cyclase domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0002383-snap-gene-0.8-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002383-snap-gene-0.8-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0002383-snap-gene-0.8-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; maker-uti_cns_0002383-snap-gene-0.8-mRNA-1; maker-uti_cns_0002383-snap-gene-0.8-mRNA-1; maker-uti_cns_0002383-snap-gene-0.8.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR23050; CALCIUM BINDING PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 2.
DR   SMART; SM00054; EFh; 4.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 4.
DR   PROSITE; PS50222; EF_HAND_2; 4.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1146..1181
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          1182..1217
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          1219..1254
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          1255..1290
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          279..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          384..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..1005
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        960..977
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1298 AA;  141847 MW;  7F9B5ADE7E141314 CRC64;
     HGVEAPDAAR ECRSYAQWPH ANGGGVIGLQ TPPPRRQLFR RADGVQVPAE RAAAKPSSEL
     PPLRDVAEVA DDRAGHNLDS ALIAAHPHAE AELEILAAPD LHPWVIAAEL SKEGPVYGEE
     AAWHSGARHW IGAACSAVPG LAPGARRERQ TRPVETAYRH SLRGHVQEGQ RLAADHVDVG
     HGHRSSAAGH SVQQGLQPAF GAFDVRVQEK AGRAARRVDA SSTRMTSCSR FGGDLSSTEC
     SVLSSADQAS LCAQTMTLVL GRPAAVQLFL RQASGRKSCR RRRGPIRSLA NSLKPLSRQP
     ASNRSRSSAF SRLGSTHTGA PRSPGPPAAD VGAPVDGAVK LVFMADVAVE LVASSIMRML
     RSRQHSVAGV GVIVEAVIRV DTEQRSYQGQ PQKRGDQKQK TKQRVTPPEQ PNSHNQTYFC
     FLMLLWRKTG GSVPLAIVEE EAPSGCPAEK LSRNPFPSCA AQTACFLRTI LLMCWTVPAH
     QRLGEEQASF SLREIIYFGP MKRYAVETPE QAETMPQLTH IAESARNRHR IQAEHPFASP
     LRANILLPAT VRQTQPLAGP TPLCRKQRLH CHVEGHRLGS RSTLLRKPRQ CLQEGATAAY
     RTDKNLRDVA KLASRQPASS GIRALRVARR QQRPSEEAPD AYRLKFDLHV IALIFEAGQP
     TCCSASRAPT RCRISPDVAA TARTAVQQSR AGVEDRKLYA LPECLSCQSE YFRTKIATVG
     DASIRLMGKR YEDVQLFLSL LYRAASLACL LEAAPAMLAM ADEFKAQTRS CIADRQQVPN
     LKATAERVLV AGMRAGRMSP VRGFLLARRH TSRQMEDCAT PLMPLADLDK DAAFAELPDC
     DRSLLLLKKV QLMEGKRFPA NQSVRNDVSI EERYIAVYES DFVIKLTRLC RRTASMFSRR
     CRSLSMRTTL SAETATLQTP PAASTSSKAM TNEALSCRTL AGPLTVFLLF IDTGANTQSP
     SRMLRLSPSS RQIKSGSGTK RLWLPPRAGD QACDTRSTGP TRLRPSLPTL LMPILEMVSE
     PAVATASRAI GNLAADSRIG EAICHAASAS ASDFIFIFKS VNSSFAPSIQ HRTPSVDPTG
     PESKQKVAST SARQLTKSFC KLVQQGLELG MHTARCNVLN TRKMKMSAGS ARRPGGSGNS
     DELTEDQIGE FREAFSLFDK DGDGAITNKE LAVVMRALGQ QPTPDELKEM IKEVDQDGSG
     SIEFDEFLEM MKKQMRNADS EDELRRAFRL FDADGDGFLS PAELRQVMLN LGERLTKEEV
     DAMIEEADTD RDGQVSYEEF ARIMGYGDDG EAEGENFS
//