ID A0A1I8GNL1_9PLAT Unreviewed; 3732 AA.
AC A0A1I8GNL1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=G_PROTEIN_RECEP_F3_4 domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0002600-snap-gene-0.6-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0002600-snap-gene-0.6-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0002600-snap-gene-0.6-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR WBParaSite; maker-uti_cns_0002600-snap-gene-0.6-mRNA-1; maker-uti_cns_0002600-snap-gene-0.6-mRNA-1; maker-uti_cns_0002600-snap-gene-0.6.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR Gene3D; 1.10.10.1450; -; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF13565; HTH_32; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2666..2691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2703..2725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2737..2759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2780..2801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2836..2858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2878..2899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2666..2931
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1762..1786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1947..1974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3067..3097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1051
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1080
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1482..1512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3732 AA; 411389 MW; E90060B66D306358 CRC64;
HPRQGSAWSY AEQPQHPAHH PPVVHHRAEH SEFSPTQSEP PQATVQNRLR RICPDLNCST
TWTTPQPLEH IFCRSTAVPT GSTSIRYRLE RADEQSPSAA VSTERQLSQQ SEPVAGRCCL
RRPDRPDPQY GTSSATRRQP SVQNRRRARL QITCTRRRLG RRCVWISTQA PPQTAIEGPK
VELELRMRRN RTRADAADDS GGALAEDGGF TVSRPIESTD LNDRAAIRPL DYDYNYPPPD
LRTRLSEIYV MASTTNSTAA DATTDAAGPD NSSTRPTYDE MIRAVTEEVR RRLEQANLGQ
PQHHHHVYQP PQQPDRAPVP KPVKIQRYTP NQDFNVWIQA LEERCELNGI MDDRRKKAEV
LVNLDIATTY PAVVRMELPD NLTFGEFKQR LSERFTHVAD TLEYREQFRC CQQGKNESVD
DYGDRLIALA DRAFPHFTPV QKQAELVDQF TVGVRIAQSA REQLILVRPQ NLTAARRAVL
RLETAASLAQ RVAPPPAARH VRVLEDDDCQ PPTGVQHDKS PRPEENWLRE VMEQQSETLQ
EQRRLLEALS NEMREFYSRG SRDNDTPEPY EPARHQPRDS WGQRNRSQQQ LGKRDGWTRH
RGQRHPAAEP ALKSPPRTLV AQQATAETAS APVQNSAPKR PRRDPFITGE INGRYFAFLL
DTGSKCEVLG FSTWHRLCID DPSLRGQIKP CLERIVTYNG EPIKMAGQLA IKMKIGNFES
TVNFLLAQGS HDNILGFEFL EKHSNSLDLA AGMLFFKNGT AAPLRYTRAE ATTCRIYTAE
STTVPPLSSA RIRIKLAKGR EDNQGTPAVI EPLKPARRED EVQHLDAAPA LISMVNGEGA
IEMINRGTTS IKVRANALIG IARPLRLPEL QFYPLPQPEV SVKQIQDEDP DAWIKEVDIG
EDLSSDQRAQ RLSEFEFEIQ HRKSSQHQNA DGLSRRPEDD AECMEEAQRE AADEDQSKQP
AAITGAAAPK VLDSSHPSPP PSKKPSTRRN RRRPPTKPKE SNGEATPPAT PTADSRPLTE
LHPPATKPRP TASRYKDSQR SPTSLVSTTR CPARSRRLRA GEGEDSDHSA ARDDRCQPAR
CPRFKKVRFS LDADSAASSF SSADESGLSD SDAEATDEDR PSDTSTTRRP AQVAIMRREL
QTPNHVATAE AAPSNPTDRR RTLNLTDHIP RPVTREELQT HQRADSAISM VINLIESRQP
KPPLNQRLNM TRDERNLLAF YEQLEVRDDG LLVIHLDDVG EEEIARIVLP KSLDATVLAD
LHGSPYCGHM GRDLTIAKVR ERFWRPALAK AVSDYVASCQ TCTQSKGRRR IPAHVQSFPV
SVNRTTGFSP HYVVYGMPYR YPIDNTLDRL DVSADLPEYI AKHQRRLAET ERIVRQRLRA
EIQRREEYYE NRPKPVELQP GDLVCLANPK LELGELPKFH RPYKSMYKVV RKVGEVAYWI
RPATARRGRP AEMLVHRNNI IKVPQMMADR PQEPPRQTER PMLPYESSND SEADSADQHA
QVQPTTAQPD LRGSQLFEPS LRHPEVLAEG DPDLPDVGME NREIDDPIER LFAVDQPRVE
PVGPPAPPQP FVPPNSPDHW PEGFLADVYA AQADPLQDAI RFVEVHRPPS PPPQPQPAQW
SSGSSGTLSA PWSAEHRPTV EGAQQLAEWL LWELDTDGRQ HSSDCCTWRA LAQQHGQATA
SRAILMAAEL LSARLPHETA GAQLGLVESM MHLGAEYAAA LGRGVPPVFL NLCRQGRLAS
TAGADREARA AARAAVREAA AAAQTDAATA RPPPTRRGRG SGRGLRQFKS SFTVSRPIES
TDLNDRAAIR PLDYDYNYPP PGLENPAVGV RQEKKFRCRQ AVDHSFLLRD SRMTFVVAFQ
LSGQTFQFVK LVLELHGCNP STQPFATMAA SSSFSRYDVR SIIKFSVLPG KSTPEIHQEL
VRVLGEAAPS IQTVRKWVRE IQEGRDCMED KERSGRPRTA TTDSNADRVM ASVSEDNRRT
CSELEELLGI PHSTVHRILT ENLGLQKLFA KWVPHLLTDE QMEERVVVSR DCLRRVRREG
DGFLGRIVTG DETTKDDPGH QIVGNVRHEA AEVQEPLATA PSRAAMASLL AKAVARRVDN
ISEEVAQLFS RPRLWCIAGQ KTPFILILSE MTLWVCRRQR HLGVLVTRHR ILSGLAWLHR
ERYDFDSGLI VMRQRQSDMV FFGPSWPEDD ATTLGKIEMH DEEKPGVSPR DRKSRYPDQE
YDAFVKSQLQ SSSTLLTMRF LRLVLSIALI LCSQISERSV HLAAPSRQSV HILLVGSTAE
LFYNDVFFLN YSIDYVNSRE DLFPTMQLVP EFRFAAGQKS GSASKAFIDG YLRGFNKAIL
LGATYSHQSQ VVADLAQYYY LPQIGYSNTS PALSDKATYP FFIRMAITNS IYIAPAVNLL
KLFRWKKIGI ITTDSPIFYP ITLELEATLT AQNITSYQKA IFSNDATDAI NRLVKNDIRI
FVVVRSMAEE SPDKRFDCLI KKIGAYGPKY QWLQIGFPFT SRMQVEQSCP DSDRQLAMEG
SIEFDSDVND PAVIHPADIT GRTRNESYQD FMLEFGNQTV APQQTSILGF DLRFDAVMAA
ALAINATLAD GCNYTAEPVQ LGDDAFKRRL FSNVLRLDFA GLSGRVKFDS RGDRTAKIYI
YQIRGGSAPV DSPRLVTQLS RVSLPVAYIT GILSGLGACL AIAAMIVNLV YRKVALIRLS
SPYVNTIIGL GCLLCYGACL VMTVNDHVDE TLQSLCWLQL VFLVCGYSCA FGGMLAKTWR
VHRIFTNKQL RKLAIKDWHL FIVILVILLL DAVILTAWGF ADPYKLLVLQ LKDQEVVSDG
TLIQQTLTSC RCNNNWLWKG IIIGMKAIFL LFGIFFAWET RTVHVEVLND SKTIGVCVYN
TMVMGLIGVV LDFALPNSAV DLRHLLLSSC VIICSTTTVL LVFGGKIVAL VRDRNNRVAD
ANTVMISGLP HPLAAVRHLD CRGGALEMAN PIIESAATGP AAPQLLLNCQ PVGLRLCQGL
ALQLRFDCRL QAGRRCRRPL LTVQTVQLVL NLGRMSFKCN PIEQPVWRRS PQRRQSRPGQ
QSIAAAVSLL TPTQPPARES SDGRPGRRTG RTGADPAACA SRLRLVSRVQ PMLENVASAP
VDVRVSRVQV DHVGHSAAAI DAAADAAGAP RQGGRCRRHI VDFFRRLSST DGQLPTPMSL
VAKAAASSRS SASSSASSSA ASFLVLSSLS GSATAAAAAA AGASGTVGGA STGVDVGASA
AGSSTGGGGA EAEAGTTGCS GREYSGGAGM TVGQDVLSGT SACFELAESS ESTFSARSES
YSWRGIQTAS PAAASTSASS PAVVTATING VTLAPAEAKS RASWPLLTMP SWNLAGSLEP
GDGGSSTASP GAIECRRASS RLTMSLMRVS WCCGLPSSGS SAGNSTRKSL VVQRGALMCQ
RPRLDSKCSH INLELIWNLG LVLPVQKPLA AGSRLLASTR RPIRVAPPAG QNGFRDWTPA
PLAPPAEMNA LAGRCRLNDF RPAGGGSSGG SRRGSTPLLK QVVIEQVASS GRILPSLVRI
IRSAGPSEPR RRCTADMDWA VHKFNQPGCL PAILVAGQPQ ADAVHRPAAG QISRVIQHGL
RLGCTRGRTA GYQPHCLTET GKMISDGAAR LLGQPVDGLG HGFWRCGGQP VLGAVDSRPA
ANHQAEGGFA ATVRQSEQSV GNLLSNFWHD ERQPGGRFQR EDDSTIGWGR PRMCSGGGGK
VIAACGLAKA LS
//
