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Database: UniProt
Entry: A0A1I8GTV2_9PLAT
LinkDB: A0A1I8GTV2_9PLAT
Original site: A0A1I8GTV2_9PLAT 
ID   A0A1I8GTV2_9PLAT        Unreviewed;       463 AA.
AC   A0A1I8GTV2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   31-JUL-2019, entry version 13.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:maker-uti_cns_0003121-snap-gene-0.22-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0003121-snap-gene-0.22-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0003121-snap-gene-0.22-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-uti_cns_0003121-snap-gene-0.22-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   WBParaSite; maker-uti_cns_0003121-snap-gene-0.22-mRNA-1; maker-uti_cns_0003121-snap-gene-0.22-mRNA-1; maker-uti_cns_0003121-snap-gene-0.22.
DR   Proteomes; UP000095280; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
DR   GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006028; GABAA/Glycine_rcpt.
DR   InterPro; IPR001390; GABAAa_rcpt.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR01079; GABAARALPHA.
DR   PRINTS; PR00253; GABAARECEPTR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   TIGRFAMs; TIGR00860; LIC; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|SAAS:SAAS00457684};
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00766067};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081334};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457623};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457659}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    463       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5009319670.
FT   TRANSMEM    244    268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    309    332       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    443    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    242       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      251    345       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      339    395       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      410    434       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    339    354       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    411    432       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   463 AA;  51923 MW;  1CFE2883DBB52B32 CRC64;
     PFMAWLSRFL LLLLLHHLLL KATSEASPSS AENAKRVVDK MLKNYTRQNS PNGDSTTTVY
     IGIYVIGFYS ISEATMDYSL TIYLRLQWTD PRLSYNSSEV GGKAQIKLED NIWEKIWVPD
     VFLRNEKKAA FHSVTIPNRF MNLEPNGRIW YVIKLSITLS CEMNLKKYPL DTQMCPMMFE
     SFGHTMDTVA FKWLQPPRRP DDIPEDLTMP QFDLKNVHLK SCDLNYTTGA YPCLQMTFEL
     KRDFGYFLIQ IYIPTVLIVI LSWFSFWLNI DSVPGRVSLG LLTVLTITTQ ASSAKSSLPK
     VSYIKAIDVW MSVCLGFVFA SLLEFAIVNV YSREESSGAA AKRQQQQLRS RNRRSGGSGG
     GGLLRRVGRK RGGIGGGGGG GGGGGGSSGL RIRTDSNSPV FMRDTVLMLE EAPPPSPPQA
     QSAAPPMPKQ RPNMPTAKKI DKFSRRFFPL SFALFNVVYW LSV
//
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