ID   A0A1I8H0A2_9PLAT        Unreviewed;      1635 AA.
AC   A0A1I8H0A2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=RNase H domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0003933-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0003933-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0003933-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; maker-uti_cns_0003933-snap-gene-0.2-mRNA-1; maker-uti_cns_0003933-snap-gene-0.2-mRNA-1; maker-uti_cns_0003933-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33332; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR33332:SF54; REVERSE TRANSCRIPTASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
FT   DOMAIN          1494..1613
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   REGION          323..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1478..1500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..696
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        735..749
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1481..1500
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1635 AA;  177805 MW;  9BE92BE0F455DDA5 CRC64;
     AYRLPLSPSA SPSSWASPSP TFSDGCPVGF GSFIGGGFCG LGVTAAYSSP PKELFELRRL
     GRLPPAREPL PPAAWAGSIF KLREGRAHLQ ILELLIARHH RVGLSHAARS RSRRIDGELA
     GEDSLQAGLR VQADVLLILA LNFAVDTGDS RSRRSALIES FNFSTSAGQG SNPLLTAQQA
     QPLIAKSFNH WAPFRAGQQS VLDTLWKAAA ASSLAAPWST TSSIGDPVSD WMKPMMEKIT
     RPANTLVPQL SSGTITASRR HVRPDGELEE FVPLGQQVQL QAVYGARSSF NFDKLWFNFD
     NERLVNFSWE NSRLMEYSFT PNTSEAAGAP TEVGTAAQPD IRNTGTPGAS QSAAAAAQDN
     TGVAGQDSGP QISKKKARSI ARYKAFLQRK AEERRNAKAA PPATSEEGAG NSANPAEEPT
     SDKGVDPARR SDASGAAEAP GAAGPSRDRT SARVEAPTAV EGSKAGGAGQ TTKPKRTYAA
     MAKRQPALVI QGQETPLTAE QLDLIWRRLD SHLVKMALSG TIIRVQKTKV EDQALYIQPA
     DSQTAALKTF DWGTELENLF IYREDERPRT HRHRAWIPAR SCITKADELR HLLVASNPEL
     PANGVVVHET ISKPGGDGFT AILGLSDSWM LRYPDMSIIS VGLLQIQLFS FESDATRPPP
     PEKRKRAVGG SAGRKRPGKE APGRHDPSED VDPVRGKAAK AAATGGRGKG RKPARNTIRS
     GLTQRAKQLL DTAKAPNRSH PQPSVTTAAP RKTGPRARMP PSRQEAARTT RGIPGVDILQ
     LNLHHCIAAS TNLMRVANFA KPGIILLQEP WTKKAWHRPD LSDRDLCVIQ SNHIITNRTV
     IIASIYIPGD GPAVPPNLTS LVDYCSNRRF ELLVAGDINA HHTHWGSNSS NSRGEELLAY
     ICTTNTEFCN IGGTPTFDNG RWTEALDVTL VSHGLAPLVK DWEVWDEEES LSDHRFVRFR
     LQSSCPKPHI LWKRNVRNTD WTAFTETLKC QTDQLTTVAP TTCQEVDDLA DLLSKTVLTA
     HEASCPLKAY KGKKSAPWWH PALGSLRRKA KCLQRKARKS KDPADLAAYQ EAIRDFKRET
     RKAKSDKWRQ YCAELEGTRP TSRVVKALTL DKMSKLSVIK RPDGRLAENP GESLDIMLTS
     SFLRAAPQLG PPDHSPGGQI LASTIITRER TARAAKSFSP FKSPVQKGGP QGGVLSPILW
     NLVMDELLCS PHPDPVQKVG YADDVTATVA GPSPAVLRDL LQAFIHRAER WAHSCGLRFS
     ESKTVAIMFT SRRNWRIEPL SLYGKPVAME KQTRCLGVTL DHRLSWTPHV QTKARKALAT
     LAQIRRAFGA TWGLTPAASG GFTLPLPAIS FAGFIWNSAL EVKGVLEVLN RVQGRACRAI
     MSAAPSTPFA GMNSFLDIPP LDLFVRGEAM KTTRRLLDAG VQIQKQFAFR KRNLRPHGDL
     SLRDLEAARG LLTLSDGIPS TLCPRSNSKP AFHHAMKRET TGNPMKSTAS LTGPKSTPPL
     DTATASWRTV ATFSQHTGTC STVFQNEVLA ISSCAMELYN QRVWGKEITL HSDSQAAIHA
     LERTTTCSRT VLDCIGQLNR LGASNKVSLR WIPGHSGHPG NELADRLAKA GSTGSFTGPL
     PVAPTPIAVV TTRIN
//