ID A0A1I8H2I9_9PLAT Unreviewed; 354 AA.
AC A0A1I8H2I9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|WBParaSite:maker-uti_cns_0004092-snap-gene-0.14-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0005959-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004092-snap-gene-0.14-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004092-snap-gene-0.14-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0005959-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A1I8H2I9; -.
DR WBParaSite; maker-uti_cns_0004092-snap-gene-0.14-mRNA-1; maker-uti_cns_0004092-snap-gene-0.14-mRNA-1; maker-uti_cns_0004092-snap-gene-0.14.
DR WBParaSite; maker-uti_cns_0005959-snap-gene-0.2-mRNA-1; maker-uti_cns_0005959-snap-gene-0.2-mRNA-1; maker-uti_cns_0005959-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR024657; COMPASS_Set1_N-SET.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR044570; Set1-like.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR PANTHER; PTHR45814:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR Pfam; PF11764; N-SET; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01291; N-SET; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 215..332
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 338..354
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 22..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..63
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 39490 MW; CE8A00A2BD3E6F1F CRC64;
MPANKRKPSL TSAAGVRELV GLFPAGPPPA KRQRPQFLPD ADTYDSVLLP PPPPPPPPPQ
FEQRSPEAET ALNERILAGV MSAEEHEMLK QAFDLLVAEG GLPCAVETHW TDHPPVGQPA
RETGPREPHS TGCARSEGFY KLTGKQKERS ALALAAAINA EAGQADEAEA EQEERKAKLS
LTREARSMQR RILAEFADIE IGDLLKFNQL KFRKKKLKFD RSGIHSWGLF ALETIAQDEM
VVEYTGQIIR RSIAETREQA YERAGIGSSY LFRIDDAFVI DATKCGNNAR FINHSCSPNC
YAKVITVEGE KKIVIYSKRE IRRNEEITYD YKFPYEEEKI ICLCGTASCR GTLN
//
