ID A0A1I8H3E7_9PLAT Unreviewed; 2297 AA.
AC A0A1I8H3E7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0004217-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004217-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004217-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR WBParaSite; maker-uti_cns_0004217-snap-gene-0.3-mRNA-1; maker-uti_cns_0004217-snap-gene-0.3-mRNA-1; maker-uti_cns_0004217-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR CDD; cd14691; bZIP_XBP1; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.10.1740.100; Set2, Rpb1 interacting domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR042294; SETD2_animal.
DR InterPro; IPR013257; SRI.
DR InterPro; IPR038190; SRI_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR46711; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR PANTHER; PTHR46711:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE SETD2; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF08236; SRI; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00338; BRLZ; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1114..1169
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1172..1293
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1613..1646
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 2051..2114
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 1..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1973..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2157..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2259..2297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2062..2117
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..50
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..413
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..746
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..811
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..853
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2297 AA; 242680 MW; 71C3CCA33C95695F CRC64;
MPVQAVNRAA PPPPPPPPPP PPPPPPPPPP PPPPPPSSSP PRPPARNLRK SPPPSSSRSD
IDDDFDGDKD FGNVADIPLP DQLPALEHTA APPPPDLSHL SAGSHHSASS GPKLPESDSG
PASNAGQAGG GSGGGGAAPI GNRRAELFLP NAADIEKTPI QPFESGSGGS SMPSTTAASS
SGAALTGSAS GSRTRADSGN RSGSSVVTES SAAGGITSLM SSSIGGVSSL GSGGLASLSG
VGGLSGLSGL GGVGGLSSLG GISSLSGSSA LSNLGLPSLK PSAQGKPKHN RPNLLLAAKQ
AAEAPPLPDV SHLNPAALPP IPGALMTRQE ADRLRSSRER ELLMMHQRDD GYVQRDPGED
DGGGEGGGSR RRRRSSGSHG HRHRHRKRRR GSRSPDSRRH RHSRHRKSSS SPRRSHRASS
PGASPKRHHG GERRRSTAEA SKNNGDGGAA KPGGGRRESG GSSYETLSDE EPQQLTDTEM
GLSDADNRGA AAVAAGTELR ELPEVREKVH MSFSGGDSGA PATGSGANAT QRRNTSASKG
QLKSTLAEFG EDDDDDGCEE ADKAGDEKSK ETKAAESKSA AVEPVEAPQR EDDRRPQSQL
RRSLSKDRLA SRSAPTAQEA TESRRSSERS KDRVRERSPN DQSGERHREE RRRRRSPTPP
TQSRHRHRSR GNSRDAKEDG DRGKEGKHEK DRHRRHGDSN SGSRRRDDNG RNRHGKSRSK
RRHRRDDDDS RSASSGEADS SSGRRDRSQR HRRRRSPGDS DGSAGGGGGG GGVSGAAPGG
GGGHRQQNQR QRSRSRQRRS RSGSRSRQHH QSKRASAAEP SADETSAASK AEERERRHLE
RQKVKERLRQ VDAMIQRQRS GGGDTGDDGS AVRSGNGDAG ASGDRLHATR QESKAAPVRV
DQPKQQPVAA TVGAAVGGKP ASKTGSSADA NAAFKQLTDF FGMLTNFTKQ MQSQVAMQQR
ELSRLRASDS GPTTAAVSVV PTTPPGRPPP APRPDDTAGG GCSSDMSVAS STSPMRGDGG
GGASDRSINE VELDEQDRQS LLAGCLSSDV AEPEEPHDDT LDSSAAAEAA AKRAAAAAAL
EPLEPAAPPG MSPPSYELLQ RSVPLAKFLP TEPACGWPCD CSVPTPDQAA RGAEACGSDC
VNRALRVECD NRRCPCGEMC TNRRFDLPPS ALPLEPLYLG ARRDWGVRAT SSVGAGAFLI
EFAGELVDWS EFWQRRAADK AAGKRLYFMP MGASLVADAT ANGNLARFVS CSGSAGVEAN
TEAQVWVTGG QRRLGLFARR DIARGEELVI DCRFLSWPAA VGAETRCSCC GKPSMTLDFG
HDASQLLTLE TVTQPNEVIS LLRALLHQRD LPIEARTRLL QLLADAAGPA VADCLLTLRR
HHGLQLTAAC LTEAAPNCCS NSSSSPNTQL VLAALRTMAR VPLASADQLA RASVADSLQQ
LLRRLSGDRD AVGQLAAELL ARWDRLPNET AAPGSGAAAT ASSTASTQAA APDASLALTS
TTPQPTADSC AAAEEFDRLF EAYAGMTEPD RKQLQAAALA GSSGGVHAIL CRVLEAMLLR
GGSGGGGFHA RSAAMAGCVS QEDLADAAAA DPNVHRLLLA VTQRGDAAVA ASGGLPPQWR
SARDPDGRVY FYHLGTRRTV WRDQPGSEHS WEPTYPWDAL PEETAAEPSA AASEAAFEYN
GAWRFQVSHD EIQDMITRNA VKIRRRERVE KVEQRRREVA SSRELQQKAA FTASMKEFVH
AHLQRYCAAT CQTGRITNQE DLKYLVKKMT HAILLKELKH TRHIEDLEVN ANVQGKAKSY
ISKYMRSKGS VYCRTGRPSA SGHGGPALHL KYFIINLLHQ KNITHPASLC NAEMTINASS
KVVYALLQKA GIAGPQMCLV EVPGGNGKLA LTQQQQQQLF KRADASADFV DVSESAAPPA
STCFVGGGGS GTKIISPADS SQQHFRKRKM MQEPRLLDME DAQPARIVLG STNPASALSP
ALSTSTSSSS SVAAADSKIR TESENLVLQK APLDSSTYST LSFDEFEDDD DLLGSSIYGR
KRARLNHLTA DEKLTRRKVM NRIAAQQARD RKKQKMEKME SALQRLEVEN RYLRCENSEL
KEKLEKLGSR LNHLLVQLEG GCGQGVSALS GARSTRQTGQ QCLWPTLSSR NQHRRLLPLG
SSRGGRPAPA ATAGDSGQPA QVSGLDGRHL ATAAGAGAET ACAGTLDAPA FAVPDVDWPV
AAEPAGADGG DLLAGLGDLL FDQSALNQLD SLLLCDSPDA PSSESGVFSD APLMPGLASA
ASPDSDDLSA LLDINSD
//
