ID   A0A1I8H422_9PLAT        Unreviewed;       717 AA.
AC   A0A1I8H422;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE            EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004168-snap-gene-0.7-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004168-snap-gene-0.7-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8H422; -.
DR   WBParaSite; maker-uti_cns_0004168-snap-gene-0.7-mRNA-1; maker-uti_cns_0004168-snap-gene-0.7-mRNA-1; maker-uti_cns_0004168-snap-gene-0.7.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 2.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   PANTHER; PTHR12121; CARBON CATABOLITE REPRESSOR PROTEIN 4; 1.
DR   PANTHER; PTHR12121:SF34; POLY(A)-SPECIFIC RIBONUCLEASE; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          287..646
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   REGION          98..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..568
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  79460 MW;  AB279D6F3C78E0DB CRC64;
     YVSLVFTKKH ASLHLGQFSF ASSIGHNLTA LLYSGSRQTR GERGQRVGLT PLSNTQQHLQ
     TLRSGLTSEP FPAESPMMPS LRRRAEVRVG QLPAFGNFQD FPDDDSSSAE TAASMPASCR
     RYQHRRAAAE ANQQQSRRPR AVPTRRLTVR RRCSEWTSMT FSATVQLDLT GVSDIRAEVA
     YHGQASGCPK SDSSKNQSDD VEDRERKPTS GLTSATTSTS SWGGRSRFVQ VRNPLCVPRC
     SDNLGTWRTC MVPIADLERF AFMKPPRQRW RNLAQPSHTD ETVFTLMSYN ILSDQYASAK
     TYWYCPDWAL AWSYRRQGLM EVICCHLPSV LCLQELETEQ FFSFFLPTLE AKGYDGIFSP
     KSRARTMEAR LRPHVDGCAI FWKSNEFSLV EKQVIELNQQ YLEQCWTSPK PSADTAASSE
     IFSRVSPRDN IALAAVLMPT VGASKSSDNS TSSRPVLVCN SHVHWDPQHP DVKLIQTMLL
     AGALAAIIGR HKNCLPLLLC GDFNSLPQSG VIEFITLGSV PRSHPDFRRL GEDPSLDGLQ
     DAAVAAATAA TPAAPGSTEA TNSEASSVAA PDGKDKRFFH QLGLQSCYSG VDTAFTNYTH
     DFKGVIDYIF AARQHFRVLD CLDGLADWFR SEAVLGCPNA YVPSDHIPLM VRLQLTRQRA
     LTTTATTKDS AASKSFFLPT LEAKSYDGIF SPKSRARTME ARLRPCVDGC AIFRKSN
//