ID A0A1I8H5I3_9PLAT Unreviewed; 464 AA.
AC A0A1I8H5I3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Divalent cation transporter {ECO:0000313|WBParaSite:maker-uti_cns_0000259-snap-gene-1.5-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0004366-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004366-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0000259-snap-gene-1.5-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0004366-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749}.
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DR WBParaSite; maker-uti_cns_0000259-snap-gene-1.5-mRNA-1; maker-uti_cns_0000259-snap-gene-1.5-mRNA-1; maker-uti_cns_0000259-snap-gene-1.5.
DR WBParaSite; maker-uti_cns_0004366-snap-gene-0.3-mRNA-1; maker-uti_cns_0004366-snap-gene-0.3-mRNA-1; maker-uti_cns_0004366-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF7; SOLUTE CARRIER FAMILY 41 MEMBER 1-LIKE PROTEIN; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..238
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 314..453
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 48561 MW; EEFF3070481CB52B CRC64;
MLDGEAGSAL SGGALRQRGS SQQDSEMHQQ QQQPSKQLHQ QLHLQQHHAL SESTVSMALQ
MAPPLAVAGL GMSLAGLVLD ELQRWPEFVR HPELLVMVPA IIGLKGNLEM TLASRLSTQA
HLGTFNETSR LRSLVWGNLV LTQLQAVLVG FLAALVAILL NSTGGGGGAP HGSSSALERG
LFLLATSTAT ASLASLLLGL VVSAVIVASE RCRLNPDNLA TPIAASLGDF ASLLALAWLA
RQLDGSGMWP MSCLLAGYAC LLPVLAAAAA RNPFAQAALR QSWLPVLAAM LASSLGGLVF
RRCASRLPLL ALFQPVINGI GGNIAAIQAS RLSTCAHRLP DESTADLPPA CQQLFCGAAG
GSRATRLLLG LVVPCHLLAI CCVLALAPDG AFSISAAFLA CYLAACLLQV AILLWLANWV
VYWIWSFGHD PDSASIPYLT GVGDFLGAVL LAAAFTALTA WQRL
//
