ID A0A1I8H784_9PLAT Unreviewed; 1006 AA.
AC A0A1I8H784;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=WD_REPEATS_REGION domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0004775-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004775-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004775-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000256|ARBA:ARBA00009341}.
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DR AlphaFoldDB; A0A1I8H784; -.
DR WBParaSite; maker-uti_cns_0004775-snap-gene-0.2-mRNA-1; maker-uti_cns_0004775-snap-gene-0.2-mRNA-1; maker-uti_cns_0004775-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR021893; DUF3504.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22850:SF27; CHROMATIN ASSEMBLY FACTOR 1 P55 SUBUNIT; 1.
DR PANTHER; PTHR22850; WD40 REPEAT FAMILY; 1.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF12012; DUF3504; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 20..86
FT /note="Histone-binding protein RBBP4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12265"
FT REPEAT 171..205
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 221..263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 267..303
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 311..346
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 368..402
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 831..959
FT /note="DUF3504"
FT /evidence="ECO:0000259|Pfam:PF12012"
FT REGION 434..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1006 AA; 109496 MW; C061251543249B52 CRC64;
MAMEKDPNYD DTVEERIINE EYKIWKKNTP FLYDLVMTHA LEWPSLTAQW LPDARGKDYS
IHRLILGTHT SDEQNYLLIA SVQLPNDSAQ FDASHYDADK GEYGGFGSVS GKIDIQIKIN
HEGEVNRARF MPQNPTIIAT KTPSSDVLIF DYTKHPSKPD PSGECRPEIR LKGHQKEGYG
LSWNPNIEAH LLSASDDHTI CLWDVHGQTR DKNLLDAQTV FTGHSSVVED VSWHLLHDRI
FGSVGDDQKL MIWDTRAKSS SKPTHSVEAH TAEVNCLSFN PFSEFILATG SADKTVALWD
LRNLKLKLHS FESHKDEIFQ VQWSPHNETI LASSGTDRRL HVWDLSKIGE EQAPEDAEDG
PPELLFIHGG HTAKISDFSW NPNDPWVICS VSEDNILQVW QMAENIYNDD EAAAAGDKAR
AAQQEDLESR VRFPAPRHPF SLAQRDKGMS SDSVRVVFSP QRQRQQEQAA AAATAGGDAA
VVTEESMLAS VNGVGGGGGG GGGGGEAETS TAGQEQPAPA PNQRSSQRSS TGSRSSTFPT
VPIEMIRQLA IEQHAIIQPV APLPLRNKIT QCQPSPVSRR LQAAPTLSDA GVQAAVNPDA
ALYGDGSKGL LPCPLPLYFP APAPLPPDPV PVPVFVPIPV PIPVFLLLES PDPEQPPHLA
LQTPASAASQ TASMASAAAA VTDVASFVEI QRRLADDAAS LVALARRPVR QQQQQLSLKF
SYGLTAWKNW SRSVGGEGTA GPPADPADLT PASALADALA RFVREVRKPS GEEYAADSVY
YLCLGLQGHL AIERAREENI FCDPAFAEFA AALDSVLDRY SARVTEDGTL VCRIEEQHLW
ECRQLGCHSP DSLIFSLFYI LTRYVGLHTV QEHAELTLGQ FALASPASGG AGAVLRFTPR
SGYAVGITYE LGELTDPTRC PVRLFQVYLA KRPLLTGRDE PFYLPTDRRA GPEDAVWYSG
GSEDPGSQLV GLPAAELQRW LKSSALRQGD PGGADAGADS MARRGA
//
