ID A0A1I8H7V4_9PLAT Unreviewed; 2214 AA.
AC A0A1I8H7V4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Gamma-tubulin complex component {ECO:0000313|WBParaSite:maker-uti_cns_0004696-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004696-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004696-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
CC -!- SIMILARITY: Belongs to the TUBGCP family.
CC {ECO:0000256|ARBA:ARBA00010337}.
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DR WBParaSite; maker-uti_cns_0004696-snap-gene-0.2-mRNA-1; maker-uti_cns_0004696-snap-gene-0.2-mRNA-1; maker-uti_cns_0004696-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005815; C:microtubule organizing center; IEA:InterPro.
DR GO; GO:0000922; C:spindle pole; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007020; P:microtubule nucleation; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR Gene3D; 1.20.120.1900; Gamma-tubulin complex, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR007259; GCP.
DR InterPro; IPR040457; GCP_C.
DR InterPro; IPR042241; GCP_C_sf.
DR InterPro; IPR041470; GCP_N.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19302; GAMMA TUBULIN COMPLEX PROTEIN; 1.
DR PANTHER; PTHR19302:SF13; GAMMA-TUBULIN COMPLEX COMPONENT 2; 1.
DR Pfam; PF04130; GCP_C_terminal; 1.
DR Pfam; PF17681; GCP_N_terminal; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF12874; zf-met; 5.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SMART; SM00451; ZnF_U1; 6.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701}.
FT DOMAIN 1509..1703
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1883..2044
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 161..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2214 AA; 241251 MW; 669B9D2E1024942A CRC64;
MLGHQDHFLL AAFSSHHLVE YIIFACNELT MVKSKDFGLY FSQQMADINH ARVQLTHHVS
SLFSQILGAD KPSVELDTYI DLLERSVRPN TQSLLADAHR AKRIISDNNP HAEEFNRKYE
ELKIKNVKEL DPFVDLLSRI KRDPATQRTL EAIAGPVQLP TSAGSAAAQP RRPQTAVGAP
AGSTSRLNVA ALSSHMNAEA RQRPTDSSLP SSVAGPLRQK TPASEPAEVP WQPDWLYERP
FLSSDFVLDD PPRRLTPSIG VYPVEAQEQL IIQDVLSLLS GVEGSFVVPR PLASRADRRG
FDVDNSLDAT RLEMLGQLLP VCSHRSDVTR FAEDKAAYEY GMVNQALSGS ITALLRDLGV
LVCQLEHQQR IGQLRLHRLH CCLQEPARVL ETLAEIAHDV NQGECLGGSV LSLLHDKACA
SAGDPKRHRL LLHLTKAASR PFFDMLQTWV YRGRVLDPYS EFMVTENTAT SKEVLTREYI
NDYWENRYQL CSQRVPSFLW PMAEKVLSTG KYLNVVAQCG EALLDYPAEE LVYAYEGGRY
VEQLESAHAK AAALLMRLLR EKGLRDLLCS LKRFFLLDQS DFLVHFMDLA DSEMRREAGR
VSLNRLESLL ETAVRTSAAG PDPNRDRLRV ALLPHDLIGQ MLALVSLREA APDATAAARL
TALEAFSLDI EVDFPLSLLI NRRAITRYQM LFRHLFYCRH VERLLGSVWL QQHRNRASVT
SAYALRQQML TFVQHLEYYM TFEVIEPAWH RLWTQLDKVG NLDELIERHS HMLTSCLSDC
MLQQPDLLKL LYKLLAVCVT FCNCIARHGG SAESADLAAT VETFSANFSG LLKQLIEAIA
EHCSNQRLNL MNLIYRLNYN YFYVAATRML YRLQNQVNSN RCDLCGVTFT SAVHRSDHLS
GRPHQRAVSR ALHAEPAGEA FCCLICDVAC NSEASLAAHC RGQAHQRRLK MPEALEYVRN
SAEHVRQEDR GGGVVWYWCD LCNIHATSKS DLASHFQGRG HKNAVVRAGV GAPSLAFDAS
ETSSSIVLPG NQQQQAASST QPLVPNLEAA AAAAAAPNSI PNHSARIAVA SLTDEFSLMS
VHPAAQVSQS PLPSLQYASQ TVQPASQTVQ SVSQTVQPVS QTVQPVSQPV QPERQPLQPA
SQPVPPVQQP QLHSEILSSP WFQFESEGRY RCNLCGTFAT SMSNLADHWN GRPHKNKARR
AAATASHMSS SAASPSSSAA SSSSSAVSPQ SVPPQQRPAD SVAPAAAGGG SQRQSAIRSA
STLGLNFDLN GKCASPINLA TWGIDLCRRF INCRGLQRRS LALGRLQRRS ISLRWLQRHS
LALRWLQRHS LALRGFNAAA SPSAVSPSAG SAALSGSAVP HQAAGQAQPL VESQANGMLR
CTVCNVQCNT PDQMLNHKQG KNHLKRLRVS GITQPAAATD RAGPEPDLQA ASYQPVVQLP
DGYSLCNLCG IRLHGNNVAA HVAGRDHRRR LAVRCPAPDR QAPACEFVAN PRTDWPTQLR
PRIYQLEAYR LCCRHGNALC VLPTGTGKTM VAALAILAAL EANPLRSAVF LVDKVLLVLQ
QAAFLRAQLA QVRMRRFFRP LPPPSSPALP TPTVTRSLAV AAVCGDLHSL PDDQPLAAAD
LVVTTAAFYA NCLRTGALRL DQACLLAMDE AHHCDALHPY SLLAGQVLSM PELKSPRLLG
FTASPAGQAS LPATQEMLVG LLDRLGGARL AWPSSPDAQA QLAEFSVRAG ISGRLVPPLT
EETAAVAALI NHSALVLTAL RKAAEASGAS DAALLVNQLL SNGGLDCPNL AGVLDEVAER
TADSQPVRLL VEQLRRLSEL RSALGLAVCG DSRQLVAELD DAALSSLLSR ELLTEMRQSA
EALVDALQLL REGQAATAGA GSVLRALADD LRGTGGARLA LVIVRERATA RRLADLLASH
SAFADFADLR PACLIGHGAA GDAGMSVAQQ RRLLYSVARG EANALVATPI ACEGLDLPRC
DLLVLADPPS RVAALVQSRG RVRVDAGRCL VYCRSAEERQ RLQDLLAGEA NLLQAPPPAA
PSSSSLCASA SHFPGQLRVL HGRANQPACP PVAEPQCSSL HLRRPPARLY ASCSRTVDFR
VSRRVSCKMQ QRRLQFHCPA GGGGPGSGKK RLELHGKKIP RESRRGDARS LFEEFELPGS
PAPCRRPRSR QQSLISLRSP ARTSQSFRGV RGWALRLLLL GSRAPPGAAS HAVY
//
