ID   A0A1I8H9C5_9PLAT        Unreviewed;       701 AA.
AC   A0A1I8H9C5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000313|WBParaSite:maker-uti_cns_0004949-snap-gene-0.12-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004949-snap-gene-0.12-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004949-snap-gene-0.12-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8H9C5; -.
DR   WBParaSite; maker-uti_cns_0004949-snap-gene-0.12-mRNA-1; maker-uti_cns_0004949-snap-gene-0.12-mRNA-1; maker-uti_cns_0004949-snap-gene-0.12.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 6.10.140.1910; -; 2.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   PANTHER; PTHR47735:SF10; POTASSIUM VOLTAGE-GATED CHANNEL KQT-LIKE SUBFAMILY MEMBER 1; 1.
DR   PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
DR   SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        123..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        157..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        303..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        328..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          124..359
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          533..641
FT                   /note="Potassium channel voltage dependent KCNQ C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03520"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          679..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..27
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..54
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        679..695
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   701 AA;  78013 MW;  040057979985DE56 CRC64;
     MSTDSSQRLL LPPRAPPPPP PSPLPPDSVE LRASGSSVGN GPTTTSAQQR RHRLSTSSKV
     SRGEDAETAS RSATADESPG TMKHLDDLMR QYQLQRARML PAHLSTRTRI YNFLERPAGW
     KCFLYHFLVF MMVLICLIFS VLSTIEEYAE FANETLFWME LVLVIFFSVE YVTRLWSAGC
     RSKYIGLRGR LRFARKPISV IDLIVVVASL VVLAVGSNGQ VFATSAIRGV RFLQILRMLH
     VDRQGGTWRL LGSVVYIHRQ ELITTLYIGF LGLIFSSYFV FLAEKTDGED SNRSTDFNSY
     ADALWWGVIT VTTIGYGDTV PRTWTGKIVA SCFSVFAISF FALPSGILGS GFALKVQQKQ
     RQKHFNRQIP AAATLIQCLW RCHASSAASH STATWKVFTV PMQQQRHHQH ISAHLYQQQQ
     QQQQQQQQQQ QQQQQQQQQS DQPSNQPSSP PFSMQRCGGD FRAIVARRAS VLSSRKRRSG
     SRQSKDASSG CGGVSEGDDG ATRGLNDTSD ADLDPLTSEP EQEAGKPVQL SEAQMAAIRV
     IRRIRYFVAR KNFRQARKPY DVRDVIEQYS QGHLNMMVRI KELQRRLDQT LGKPPSWSGA
     RDRGTSERHR PTVLNRMQRL EQQVNRLDAK TDQILLLLHQ LVAAAGQGRR RTAAAASGTN
     APTASAAGGS ATGLTVNAAG SAASGRRSNS LIGWTQPIIR P
//