ID A0A1I8H9D2_9PLAT Unreviewed; 1161 AA.
AC A0A1I8H9D2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=EGF-like domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0004912-snap-gene-0.4-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0004912-snap-gene-0.4-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004912-snap-gene-0.4-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A1I8H9D2; -.
DR WBParaSite; maker-uti_cns_0004912-snap-gene-0.4-mRNA-1; maker-uti_cns_0004912-snap-gene-0.4-mRNA-1; maker-uti_cns_0004912-snap-gene-0.4.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1122..1146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..87
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 89..124
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 126..163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 499..717
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 887..925
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1011..1055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1056..1093
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 77..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 93..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 114..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 896..913
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 915..924
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1022..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1161 AA; 130178 MW; 2AFC412D3583FE7D CRC64;
YNRVNGNSYC IIKRGNNCYI IGNNFAFVRR NIVRYQILVL TTTSGGVYVN VSHLCSSSPC
NNGGTCRTTS TYFECACAPG YTGFLCQTDI NECGSNPCVR GSCIDRVNAY QCVCPTGWSG
INCNADIDEC SSSPCDANAI CTNNPGSFSC ACRPELMTFS TANSTKLTTY DFNNYTVSYV
TIETEVPFVI GSKESTVCKI SKDGYLSFTD PPYQLNWPTW YTYLVKPMVF PYWSYRYAFA
YSDSAVYYEL LESSRHRNTE NWKKHISFQA IVTRNETHSF VVFNYGQFEL SEWRWWYFYV
AAGYTDGYQK FDRLPFSYYW WRRNSVTDNK IEGNVGKVGR HVRTMADSIP PSDKLKCKKW
MDNERNRPLT TTLNCHTCPR DMRQAVLDWR YSPYEYSCDQ NNKNSKGNYE LNMCFRGRYE
CVQNFANPPA CPYPWWSWYC NLFMRCQFYA APRCCYRLKV HWRKDGQLVD YCDAGYSLWT
MRWLLRNVMF DRSASGSLIR STVQGAGHSM ILERTNKYYW WWYRYDEQLR NETFGYDVCR
AGKSYPMLEL QARTGLAKSL NPNITASATV FIGFALKAGS NNCSIAVLLN TTSNDLDVYK
DDELLGSVLT YFFGQENSTV IERYSLDASD NKSITISESD TGFSVTVTRV LSLLQASVQL
DQQRHSSGVE GLMGNFNGNK TDDFKLRNGT LLPGDSSERE LFHFGQSWAL QSGDASHFPY
EIGVTRANYC NMSFVPVFVE DYKDNLLSLF YNNSELMTAA NDTCWNTEQS IYLSCMYDAA
QLQSLDAAKE ASLAVSQEVS AKAVASNTAP EFNMPSNITV YSATTFNMSI NVTDRDGNPM
TLSILQPVND TSVWLVDNIL VWEVAINISS FNLTIVATDS LGAPSSWTPI VLYVDCENGA
THSFNYTSGE TICSCPSGYQ GDRCDVSPCS AQPSPCYNIS MCHMYSNGSY YCDSCPEGMV
GDGRVCEDTN ECLETPGICQ EQCTNLAPGY RCNCTTPGFQ VSPSNTSLCE DINECLTGDH
RCRSDQNQTC VNTNGSYTCQ CPLAGFELNA LYECQDIDEC KTANPCGHSY VCVNTIGKYS
CQCPMNKIKV NGECVQILTV SDSASDSATT EPSTTESTNQ ALIISLSVVG AVVLIVIIVL
AIVFGLRARD PVEVLVDSST G
//
