ID   A0A1I8HBI3_9PLAT        Unreviewed;      1900 AA.
AC   A0A1I8HBI3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=RNB domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0005402-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0005402-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0005402-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; maker-uti_cns_0005402-snap-gene-0.2-mRNA-1; maker-uti_cns_0005402-snap-gene-0.2-mRNA-1; maker-uti_cns_0005402-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF00773; RNB; 2.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          418..746
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
SQ   SEQUENCE   1900 AA;  218162 MW;  980FC178AAD27411 CRC64;
     SSPEELARIL KLFDSCQEYD EFDTTVQSSK EKWRSKLNNV AEYRLCRMRF DQGSYPVAIP
     EAVINNVLRI RLTSRVTSIL QDERIVVRIT NRQYNSTEAE GVIEGRYCNE EKYAMLSKSR
     ISKIMARKPK NFRVCELQLE GSQQGWAVPV EATDELEKVE LKGRTNCGRA CQGDTVLVEV
     LDKDEDNPRL GHGRVVGVLK QHEKLVYKLF ICEIIYDDGS FMRPLCHSFP KIGYDNRHAR
     VWYREYYEQN VMRSQPFQSR RAIGVQNRDE RGMEDVEKYA NLHYVSVYNP RKRLVESAEI
     KRDQQKGKKG KRGLDMASKN AQSKAQFEFS PYGNPLHVQK HNCDKLFVVC YLGWNVNQFY
     PTGKVVHVFD RVDSLKSTLE VLMLKHSLPR KMLETPAVKR DLERIRTIAT DTSDHPKRRD
     FRSHFTITID NPDTKDMDDA ISFQYNQQTR VALVGVHITD VSYYIEKDSH LDKLGRNRVD
     LTGEWDLRRR TPAMTLINSN HRLNKDAVHD ILLGKEADFD VPPSQELIAA IRYLWSIAKE
     LRIHRMGSAA FVLRDQLEDA QSAIGDKFEA SALVEEFMVL ANRTVGEFLA SSKYLEPFVN
     RVQQSPRDVD VDLWRSKFEF SVVQSAELSR HFRNLSAIYD EARVPRQNIR IFKDDSRLLQ
     QLCSQDPRSA LLMLYSETRF PYLFLAISDW HKISQPARYI EFQAQQPKLP SLHYDLNIEN
     YVHFTSPLRR YPDILAHRAL RAQLEAQIQG KVESIEDLAE YMNCVMQRSK RFEKDGQCFE
     FAELNKTKPQ CLLSVVREMS EDELLFTGSS LEFLPALSKT IPLRFLSLID KPVLSNGCMR
     LQWKKKIFCH PSSERWNSFI EHGIKPERNS ECVVSSTQYF DFVDFNCAKS LKEQLLNSQG
     NYDRVRQHCE SSADRIVEIP DELVARSFFV SSESAQQENS IMNSSSHVSK EVRLGDIMKV
     QFYNVMSSGL LTPTIQMVEL CDTIDMCTAH RMRPVASFER IADEASSNSY RDTLHYANVW
     LPIVSMESAT VAAAADDSFV VHDAELLWRW DDKNKRHLGL FCLTEQYCQN RLIRFSDSVY
     HDPRRKEKLE EHAVRKSDID PTDEAFRIAE SIEGLRYAEY ICLRSKRDSH TWIGHGGIVS
     VYISPHTKSV LCGAPKVHIC RFVVFHLNEV SCDASAPQES LSRASIEVIY KFLPSRRQEI
     ALQKLVDVEK FDLASRLINL ECERRRLDAT GDWTIYLNHL RNLGVQQYVI RLPAENNLKH
     FESIPCNDSQ EKAISKAMTQ PVTLIWGPPG TGKTSTGIML TYWYVFINRC IDDTWHEADD
     YYDAMDDDQE DEEVAEDEDA ADADVRIRYE EMGIVAQPKE ARQPKQPVKV KVVAKGRDKS
     KKLQTRRQVL YCGPSNASVD VVATYLQNRL RLKCPRIVRV ASEQIEQRRY PVPGEGSKSK
     VNAETEISAE LEPVTLHEVV RTGNGKSARL LKSFDKIFRS FLQRRVKSAG AFRNVLVQML
     PSLPDLDKYL RAHLREYALL TDPTRNEPLQ PWDMDLSTIT QLYRVALSDA KSVALQRFEV
     VLCTTSVSSS GLLQKSCRFC QIIIDEAGMC TQPETLVPVV GYLRAAPAGS VDDSGAEMPT
     RLGSHYAERL VLIGDHKQLC PIIQNKTAAL LGLRKSFLEY QSDNMIMLRY QYRMHPSLAD
     FPAEYFYNVS GQDGQPNGPG LQTRRSPSWT GLKPYGNIRK DAGRYWNGVN THLLAEDSAY
     ERMLATNANV LYGCWPGVRT RQRCVEQGFV YSTMPDAHVG DLHPMGEEER VVFLHIAGKE
     KRTTVASDEG HEDSRCNERE AETAVRIYKS IMQRLSSRRF VESSIGVLSQ YRYQVSVIKQ
     KLQQEGFANP AVQTVIASQG SEFDYVILSL VRSLPEYEIP
//