ID   A0A1I8HBU6_9PLAT        Unreviewed;      1597 AA.
AC   A0A1I8HBU6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=5-oxoprolinase {ECO:0000313|WBParaSite:maker-uti_cns_0005395-snap-gene-0.7-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0005395-snap-gene-0.7-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0005395-snap-gene-0.7-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   WBParaSite; maker-uti_cns_0005395-snap-gene-0.7-mRNA-1; maker-uti_cns_0005395-snap-gene-0.7-mRNA-1; maker-uti_cns_0005395-snap-gene-0.7.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
FT   DOMAIN          4..208
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          228..518
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          960..1011
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          1042..1563
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
FT   REGION          572..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1556..1578
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..601
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1597 AA;  172261 MW;  C1664C87D3D7F1CA CRC64;
     MFSFAIDRGG TFTDVWCKIP SGKVIVRKLL SEDPENYDDA PREAIRRILS EFSGADVPKG
     SPIPTEQIQW IRMGTTVATN ALLERKGERF ALLVTKGFRD LLYIGNQSRP DIFDLSISMP
     EMLYERVIEV DERVLLAQPS SCRLDPQPGP LATGVTGSLS TQPLNMESLR TELTSLLADG
     IRCVAVLFLH SYLYPEHELA AGRLAEELGF SQVSLSHRVM QMVRAVPRGH TACADAYLTP
     CIDKYIGGFA SGFAGGLKVL FMQSDGGLAP VNQFNGSRAI LSGPAGGVVG YALTTHRQAG
     GAPVIGFDMG GTSTDVSRFD GQLEHVFETT TAGVAIQAPQ LDINTVAAGG GSRLFFRSGL
     FVVGPESAGA HPGPVCYRKG GPLTVTDANL VLGRLLPDQF PKIFGPPLIR HWTQRGQALT
     DEINAFLSAE TGQAAMSVEE AALGFVRVAN ESMCRPIRAL TQAKGHNTAK HALACFGGAG
     GQHACAIARS LGMTRVFVHK YSGILSAFGL ALADVVHEAQ EPCALEYRQD NLASIEKRFQ
     HLEGECLAKL TQQGFDKKQE IFVMLKKNHH HGNDDKLAHA SSTGSNRRQR YFNKTGTNSN
     SNSCGSGIVA TVEQPTHVPA SIRCPPMLSP FGCQAEVCGG NDNNFEALFS QREELFNWLD
     KQANNNSGES SSRKVASKET SRREVENWYY MHFRFRMQGY QSLIYAIRQS AREDSVFSED
     HLDKWTFKMR FRIRKSSPLK TALVACASRL GLESDPDVIF CIDGFYGDAL SGRVHNRNEV
     PNRVVVATST CRALGLGNGS CLFVSRASRN ERDNANMQVQ LDLLRGFVVD DGDELGYEHD
     DEGIFGRVSA TTRESKGSRS SSSESLSCIR YERYLHLRYD GTDCAVMCRG STEPNEDYLS
     VFVHRYRTEF GFTLDDRRVL IDDIRVRGVA SSGADAEAAA DSLAGGEVAV EVQQPEPVAH
     SRVYFEGVGW QTVGIYRLDR LSPGQCITGP AVVLEQNSTV LVEPDWTASL TKTADLLISR
     KSADAAASVN ETAIAESEVK VDSIQLSIFS HRFMSIAEQM GRVLQRTSIS TNIKERLDFS
     CALFGPDGGL VANAPHIPVH LGAMQETVRY QMANCELLPG DVILANHPRA GGSHLPDLTV
     ITPVFLPGSG QSPIFFVANR GHHADIGGRT PGSMPPDSHS ILEEGAVFRS FHLVRGGQFR
     EAEVTKELMA PAKLPGCSGT RNLHDNLSDL RAQVAANQKG VALVTALIEE YSLGVVQAYM
     KFIQANAETA VRDLLRRVGA SALARTGASR LSFADSLDDG SDIRLSVDID AKAGSAVFDF
     AGTSLESHGN LNAPRAVTMS ALIYCLRCMV PYSIPLNQGC LAPIQLRLPE GSLLSPSDIA
     AVVGGNVLTS QRIVDVILGA FSACAASQGC MNNVTFGDDS VGYYETVAGG SGAGPSWHGR
     SGVHTHMTNT RITDVEILER RYPVIVDHFS LCPGTGGQGQ FNGGDGILRV LRFRKDLTLS
     VLTERRVHAP YGLKGGQPGS RGSNSLEVAA TGRRMNLGAK TSVSVGPGDR FVLRTPGGGG
     FGPLASKGTS DSGAGAHQPP LVLRGTLVDY EQMQFSA
//