ID   A0A1I8HCA2_9PLAT        Unreviewed;       416 AA.
AC   A0A1I8HCA2;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=ceramide glucosyltransferase {ECO:0000256|ARBA:ARBA00012699};
DE            EC=2.4.1.80 {ECO:0000256|ARBA:ARBA00012699};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0005371-snap-gene-0.8-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0004716-snap-gene-0.5-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0005371-snap-gene-0.8-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC       {ECO:0000256|ARBA:ARBA00006739}.
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DR   AlphaFoldDB; A0A1I8HCA2; -.
DR   WBParaSite; maker-uti_cns_0004716-snap-gene-0.5-mRNA-1; maker-uti_cns_0004716-snap-gene-0.5-mRNA-1; maker-uti_cns_0004716-snap-gene-0.5.
DR   WBParaSite; maker-uti_cns_0005371-snap-gene-0.8-mRNA-1; maker-uti_cns_0005371-snap-gene-0.8-mRNA-1; maker-uti_cns_0005371-snap-gene-0.8.
DR   UniPathway; UPA00222; -.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR025993; Ceramide_glucosylTrfase.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR   Pfam; PF13506; Glyco_transf_21; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   416 AA;  47189 MW;  9FB75117AB822F1D CRC64;
     MVASWLGEIM DEITIAYILF ILAVLPLVIW IFQMLFFALA WYTCRRHLYH PKTAGDVKGD
     LPGVSIIKPL MGVDPFLEGN LESHFTLQYP NLELLLCVQD ERDPVIELVH KLQTRFPDVD
     CQLFVGGKPG VTNPMVHNMA PAYERAKHDL VWVSTSRIRA STAILLDLVA SVQSDPRVAI
     CHQLPYMMND GVGGIAATVE KLAFGCNMGR NYLALNRLGT HVFTGMSYLV RKSYLDEVGG
     LAHYGCYLAE DYFLSQALHS RGYELVLSAF PAQQMVAASS IAGYKDRMVR WWRLRLNMMP
     LVTLLLEPLT ECVPLGAYIS WAVYYLFDVN PYLVFAVHFV LWISLDYHQL RLIQNSPLPF
     RFPNFLAAWC LRELLNAFVY VEGLLNPRRV RWGKNTYRVT LGGHTTLVTT APVLPL
//