ID A0A1I8HD89_9PLAT Unreviewed; 3894 AA.
AC A0A1I8HD89;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 34.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0005456-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0005456-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR WBParaSite; maker-uti_cns_0005456-snap-gene-0.3-mRNA-1; maker-uti_cns_0005456-snap-gene-0.3-mRNA-1; maker-uti_cns_0005456-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20335; BRcat_RBR; 1.
DR CDD; cd20336; Rcat_RBR; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 2777..2797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3227..3257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3380..3409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1415..1641
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 1419..1471
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 865..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2193..2278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2348..2381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2687..2734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2809..2840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2942..2964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3173..3211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3420..3439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2069..2083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2352..2368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2810..2840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3894 AA; 417180 MW; DCB845F9D4634A38 CRC64;
RGSGSVRRRG IGRRCRRWRR ARAVLRFERH QFDEMRANEA GEFVATLAGG VCGCGGCLTA
LAGAALVGRV ARRCAALEAV LLAGCSSRLA ACRTDRRGVG LLRVRQMRRS SLRPRRLHWL
RLMTELVEAA AAAALAACLE SPAVVEVDAA VEASMVLGAA LVALFPLAVL PSETVLAVLP
LETVLAVLPL ETPLAVPSET VLAVLPLKTP LAVLPLETPL AVLPLETVLA VLPSNDETGN
AAGKPAVADV ETAGWVVASG GRRCTVAATE IAPTLAAPLL GPGAVGPWRR AASVWRFAQF
SSRRVDVMWH SRCQDLAGDA VLRMRGFDRA HVDVVQFSDV LDASIPIGGA AHGKRGADAQ
AELLLPSRVV GEDEADEVAV DEDDQVLRSS LSSRAAKLLL ESASVDTGAA AADAAEDVGL
PGGLPVRVEE DPNSRGPKRG RHRHCVLLAG VAVRFVKVAV DAGGCWTGVA RVRAYAVGEL
AEGVHGIGGA AVPGAVLPLL SSAVMLKQLS LDRFGIVSGL EGGGRLHRHQ LKAAIIVDGG
IRVRIVARRV AGIGEFVPLD GGLGLVEQRM RRLVPRVDSQ RAVQVGVGSG GQVARPGQVG
VGAAAAGIRA GCPGETGGRR RQRRCVAGHE VRAGGARRPR AERVIAQLIV LVAGRFRLIT
AAAATAVAAA ATSGGSPLHS DVAPRVVDLA ASAWHCCWLR SSGLGCLYRF ENRRRRWGGR
LLGWRPRSRQ LDHYWLSSLS CCCCCCCCCC CCCCCCLGGL ASGQRLSSIG AALTDATVGT
GQQVKKGGPL EQKNLKAGTW AHVIDAVAHQ TECLCPALSR PDRLGEALTG SADVQVRFRD
YVLLRKDTNE DELGNSKEKT TISARGMGLS RRRRASKSAS TRAASASLQP LNQGDGPVRI
KNGNTMRRTH RINKEMRNCG IVSFEVSPYD SKRYCREPTK RLISKPNANH SELDRICLAD
NDFDFRVAYS LNKKSRWDMQ DQIANQCNSG DRSLRNYSLA LLDTEWRPQG RGKLATRRLA
TNFDYMRLAA NELRSRLNSE SKLRGGKVSF SSQVEHARQA RALVSFGGHR GRVNRESMLR
AFEMPKSELE DAETLRLDSD RRTEVLVEIR KPTGGAANKI PHSRLIDDSC HSRACGRQRR
RLNCRGQALI EDDYCDFNSV DYEDSADESE ADESFHKLTA SDRSAAPTVF DAMRVKPGSQ
SSMNGKPLLP FEVEPEGTTQ QDDWILVAED DEAAEEVTAP GALSGHIDSV LLQKRPILNA
KSHLVLPERL EWIFAGTDAL CMSSSQPRKF AVLLQENLCE SVAFEVISEA NGFTKLSMRH
IVAAANSDSV RHRRISVAKL ANKSDPFEYL RGLLTPGPTS TRGLVVYQPQ YGQVPVGWCR
TEVWKETDAR VAAIRALPMF SASATVTLED SIDSAGIECG ICNNLMRTSS AAKFSKRSTA
LGGCRHRFCN TCWVRHVTTA LSAGDASVEC PSSGCRTPLD AAVLLWFCPD RLLPALAGAA
FRAWQRRLPV SRFCPLPRCG RLLVAADNGG KSALCCCWTS FCLACGKEPH WPVDCATAER
YLSEMAVKGH ANLRSRELFA VMSVRGKRCP GCQTLVEKTD GCNHMSCACG HEFCWNCGDD
YDSDHVCGES RATFIRKKFF AEDDLLAPTS ERSLIYCTAI RVRRARHEGP RLLEGQAHLT
ARLLTTVGRS ATNAEQLIAD VLVASYLLEY TCVLLDANEA NDAWQSEVRV IGERIQQLTR
SFNDELQSEG RGIGDLNDKK MAEQVVDSLV EQHEQLVTEC QRLRSIVNKF GGQFRARGAE
MLLNVLSRQI RAAVLIERFA SSDSRRLEFR IRCPAGGRRG AAAAAAAAGG SSGERHSRGG
RGGGLDRRRR VDFLAAAGWR AKQGARIWAG RSTCHWNPGQ VAYQAICPAV SASSPHSRQT
WRPAIEKVKP FKDVSTRCLG KPLMKKPPPP TQLHPQVQTY GSAPGEVKPL PPEAKQEAVT
SAAAGAHNIF VNSSRLHIAI HKSNTTVPSE LMAEAAAAVA AAAAASTANC CCCCAPGDGP
GDDARSEFRR TDSWPSRHGC GSCNGRAAGG SGISMSPSDT TKDTPAADAE AASLSDFGEA
TGARTRSEPC GGERRRPSGE AAAAGGVGQI SKQQWQQPDR SRAILMAVCD QRCGRTSDSR
LACTDCSRAT RPLASANSAS EKAPLWTCSA RARNSSRLAP REARSACQRP PWSNSGSGTR
VRPDTPAKGS AAPGTVQTES GGGKASRRAT RGLSCTTSRD ENASKSSSRL SSSSSPGQEA
FLPARLVSGV QRAAADEAGS AWRTESSRQT STKKATEALR TTVGYTWPST SVPSASCSRL
AARVRPTRVD CDSGQPSRSS RAARQRRFAP SASRRDSQAR SARRLAPGGL LQLLAMLHPL
LLILLSLPLP LRRLLLLLAV QPGRQLVSEA GPQAGHLAEA LSIPAPATKP TAPTRQARRR
VLCPSRRDSR RRLGQKLAGR APAAGFGMPT EASELRPRGC LANWRIRRSA TQLDGAATVT
LSDSAPDTSK LTLAGGGVGG DWRRSVSSCW AKRVLAAGRR PAKQLGRGAH DLLRQAVRDV
HQVSLHAANE ARVADGVLAG QQLSDSVPVA DQRHVQRAEL QIVDAVLQHW PPAEDVGHGN
GVVGFDSFVE AIGVVQDGGR AIGLRAPVLD VLVAVESFEA FDEEPPLPLR RNRARGDARS
GSEAGFALPS ASARHSDEAT KPPQLKRAAL PEPRSFGAER AHAGRLGEFG IESGRDWDRG
TPGTARKLAA TTPAAEASVG ILLLLLLLLL LLLLLLLHRM QRLKKRLVTA SSPAGNTRPN
SPARANSSID STRTRTSSGV SVSRMLRSSG RWLNHSFLAR SSEFSGLSGQ QRLSAYGAAS
LVESAIFDIA EAEAEPGAVD IAEAGSGSWK PARFMKSRMT ALLTSMSSGE FECNDGDMFT
SSSQGFRRSS SRMSKPNSSQ NGTNLRVDVR LPANDSFHHQ ILDAGPHGLG IFARLSQVGP
QRSQAPFVTF AVAFFGLAAA GTVVDVALID AVVGHAGEAD QAALVNVDSQ RIKAGHVDVN
AQVEFASVDQ VGLNHNRPPF RHLLPLVDDS DPDTPGTGRG FTIHFCLAPA SSHALRSCLR
SPGRQNVNGK KSNSRRPYWH CIRCKQRHRR SFRPIVKLPG KWVAARAAGR TLPRTAAPGH
VREQRRDDGR LAGTGHGGCP GGSAGSPGGQ QRGASASVVL KTVQQAAIVV TVVVNAIVDF
LIVVVTFFVA IVIFVVYDVA VNVACRLLSF ATSRLWRRGF EPLLLLPLLQ LRRRPQRRDE
SISDGCWISW LLALTTLPLR LGLLGQLLLD AELIELRPDE QQAGLRLVVR QLRLRLLLSR
HRVGRSGRNG RCSSSRRCQL IVVGVGSAVL VATAACLMTE TALLALLLLQ EAGSELRAGS
ADDAEVASSG RRRRRQRHRE LPRRLASLAP VVDVVESLEG DQRFVEGGNA RSSSQSLDEV
GLVAPAEVPQ SRLKPVGSAS SCQLAQAGFE RILLSIESLA AQSASLRKPS AARSSCPPSA
SMRARLSRQA AALAGLCSDS KKSAAFSRVV LRRQFLGQLS NFLVLSGSKA ELAELGVNCR
GRLQAKHCAC WLAFCVAICC VGKPSGSEVL VPRIQVALLH FQPIGLLDQL ATAAPARLEH
ASLAPVVDVV ESLEGDQRFV EGGNARSSSQ SLDEVGLVAP AEVPQSRLKP VGSASGCQLA
QAGFERILLS IESLAAQSAS LRKPSAARSS CPPSASMRAR LSLQAAALAG LCSDSKKSAA
FSRRTFLSVP VAAALTNSEL FEFLSQLSNS LVLSGRYAEL AELSVQPRSR LQTENGTAKV
LLQQIAGGSF AQTVGSIELA FSLTKKALSC FDERVASFSP SLFHFQLVRF INKL
//
