ID   A0A1I8HDL4_9PLAT        Unreviewed;       575 AA.
AC   A0A1I8HDL4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Na_H_Exchanger domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0005635-snap-gene-0.7-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0005635-snap-gene-0.7-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0005635-snap-gene-0.7-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367}.
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DR   AlphaFoldDB; A0A1I8HDL4; -.
DR   WBParaSite; maker-uti_cns_0005635-snap-gene-0.7-mRNA-1; maker-uti_cns_0005635-snap-gene-0.7-mRNA-1; maker-uti_cns_0005635-snap-gene-0.7.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   PANTHER; PTHR31102; -; 1.
DR   PANTHER; PTHR31102:SF1; NA_H_EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          135..524
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   REGION          96..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..564
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   575 AA;  61078 MW;  1DBFA623BEA9939E CRC64;
     AVKEPPDGSV REMAEPPSAC TRCCDRTCYN WCLAERHQLP DDPSIAQKLH HDLLCPPHGR
     TGRLLTGITI LLLMYATLWS LVPDRSVPGS CVTAQLPEST NSSNSTKSNQ SNAGTPSKKL
     NCTGGLFGLY LVFTISMLTG ELFGLIPRCP KLLGMLIAGC FMRSVPFLAK FALGIDKTLS
     STLRSVALCI ILLRAGLGLD PKRLRALSLH VVLLAFSPCI TEAVTIGFAS HLLLKLPWTY
     GFLLGFVLAA VSPAVVVPSM LAIGSEGYGV AKGIPTLLIA AASVDDVLAI TGFGVLLSVV
     FGGNESLALT IARGPLEALL GIVVGLILGV LLWFLPPAGH RRFLFFRFCF LLASGIISLL
     GSVALKLHGA GALACLTVAF MAAIGWRSRD GWSDEENPLL GPLEVCWRIA QPMLFGLIGF
     EIDVGSLQAD AIGYILATLF IGLLFRMIAA FVAVTGAGFT VRERFFIPFA WLPKATVQAV
     IGPAVLDTAY RTGAGPKAQA MGAQILTVSV LAIVITAPLG AILISLLAPR LLNRQVLSFE
     EKFDTEAAPP VRRSDIDGRN DSTADNDENV NGTAT
//