ID A0A1I8HH64_9PLAT Unreviewed; 3452 AA.
AC A0A1I8HH64;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0006031-snap-gene-0.7-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0006031-snap-gene-0.7-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0006031-snap-gene-0.7-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR WBParaSite; maker-uti_cns_0006031-snap-gene-0.7-mRNA-1; maker-uti_cns_0006031-snap-gene-0.7-mRNA-1; maker-uti_cns_0006031-snap-gene-0.7.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003974; K_chnl_volt-dep_Kv3.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF286; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01498; SHAWCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 2346..2366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2505..2526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2538..2555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2567..2588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2161..2295
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 151..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1653..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1780..1831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1851..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..1989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2097..2160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2803..2822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2857..2930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2951..3014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3398..3432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1480..1507
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1998..2026
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 155..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1659..1675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1851..1876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1900
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1965..1986
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2097..2117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2895..2924
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2955..2991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3452 AA; 379098 MW; 40FE9CBFA7354979 CRC64;
PANSFAELEA ELNSFDDGQL AADELSSLLL MEEPIEQQQQ SRKCSTKSAE MSAADSVETE
ETIELIVGNT GGIALAVESP PLNSTGLSSL IQLLMLITCI VLTVLFSIEV LPAICKRRRV
AIWSQRRGLR QMAENIIGQF EHSARLLIGH ELSDSSPDPR AEQQPRDAGA EEEQRRPPCR
YRHRSCCSLC CCIGGIQQQQ QQQQQQQQQQ QQQQQKQNRT HEQLCRLPPS SARRPRTRTQ
REKTKPDLKP VYTTLSPLSL SGCVPTVMRL KLKLALPQTS FRLCTMASAT ESHWETLTQA
RLRPQAVRKC RIPPARALKA DLSHSGSKEA TRDANDGGGV HSECAVRLAV SRPDAERAAN
LIRTDRPPRA RVRHRPVGRA AVDWNSQNRL HDLFDLTLPH HDLSIGQPSE RRANDARLVE
QLSVQLFYRL SSEWQQHLHN EVFASRRRRR ELAVEHLACR ISHEWHTGDP RPAVCTRLVG
RTQKRAVCNC RDEVSGFQVH KVEHLEHVCS MVSPWIQLSC SSVAVKPSVH SATTATGSLC
LVHSSWLAVE LHCTEVTESS ATNTSLPVLF VKLTDTCSLL TALIKDVRLG DGVQLAKMLT
DNPLRESSSF CQMDSEKARA YSRLAPCLDT TRPGGWSRTN LLMKLLKVHL RSAFTVSAGE
TGEVGNVVPP VELLLSLANR IFRVAPGDRR LAERAAGAAS ARPHMSDVIS LHEVSIRADL
GIHCEDLGAG WTLWYTSADQ RGRRGVGALI GPRLQQSCRC TSLSDRLLRV DVRLHGRNAR
LFCAYAPPAT RPDEAQVFFE QLSAQVEETA QRETLVVLGH LNAILRRSER SPFVTPRENG
NTGALEDFLE RQDMVSANTR FRKPPGRLAT FVGCKRRRRN ARGRNATRRQ AQLDHLLVHL
RERRRAVNCR DITPLALRSD HRLLICDLRA RRNFASAFVS ALGDRCGCAE YTDVSAAVRA
AAEQAVPLMQ PAQRRQPVWQ DDPAIRQARA ELERLRGQLA RRKRQQAAVD GAIQTVSAAG
PDAKGRMACS AINALTGRKR RIPLNLAGDT PDERRNDRPN SNRAGKRWVR TRLPIEALRL
HCVASEVASV MNRVLFGGTQ RMDHGAHRRY SEEAVLEEHQ GICLQSCAAK LFNRMLLSRW
QPVLDPYLRS EQNGFRPHHG TVAQILALCR VIEEARTRQS SLIALFVMRA VLPMVLRAYN
VPEQLISAVM ALYHGTNAAV LTPDGLSDFF ETSSWVLQGD TLAPFLFVLV LDWLLRTALP
SNDDGFLFQR HVGRRQPERR LSVLGYADDL ALLSSTVEGA QRQLDRLEIV ATSVDLVVNT
LKTVVLCVPD DIEAAIFCRG ADGQATKLPS SSNLGGLVPD VREDPTTSPW ICLGYLPFRE
GAGAYSAFRR LHACWLMPAP RTLRSYTFAY VRAQALKRAL ILLLASSAFL DSFQKIADLA
SSSNGATKEL GAALTRICLK QRTIESRAKS YSGHLQDSLA APLSERLESW RRQTQQLEKE
RHRELKRLRA DAKRSAGSGG SVIYGGGGGG GGGATSGEST LRLGRRRRQS SGSQLMDSGQ
LERALADSLR WQERQLTVER HWLRLARQEG RSRLACFLAC LKPGLDLLGG LADEFGHLRD
LADRMSGLTN CCADDGSDAS AAAASAAFNA ATGPPKMSSG GCQRRSFSPA PSVNSHGSAE
SDLYGAIGGC GSSISSSSTV RAGSGAGVSG AVPLVGLIAG SRRTGSGVGA SSSDSGFISQ
DLRPATDAVE GDQENANSVA ADAAAAVADS ADYAEADAAS VTSSTSATSD TPVAAPPAND
VDQDEPRLRH PHRQRQQQQQ QLYPDQSLPA PAVYSNLGEL QRNAARRRKF SFSSTSSSSA
VAASTTAATE TSHSVVAATP PPRPPPPLPL PPPPPPPSSL SMAASSASML RSAGGTATLR
RASVDFSSSA YLTAVAAAAV ASASSAGSTS ASTAGVVPVP PPTVPFWQRQ ISEPPPPPPP
PPPHSNSRLL SSQNRRFFQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQHYQS LSFRRFIDRY
RFSKHWTLNI GQQASCPMFS AHGGASVDAA AAASNHWRYP KQSVDHGRHC VDYFSDNEDE
DEASEASEMD DTDEAFIPEE PNEKGSVYYS PASRTAVPTE DVAESNHPQS RQNRPRHRRQ
RRVLLNVGGE RHEVLWSTLN RMPRSRLCRL RRARTQEEIL ELCDDFHPGH CSRHQQQQQQ
QQLRSRQRRR HQQQYDEYYF DRHPKMFHPI LNFYRTGKLH LNEDACVIAF DAELKYWGIR
EECFDLCCQQ KYHHKKETAE DEIRKDMEAV RWNQRSIQLD FGPGRYGEIK RSVWNLMEEP
QTSRPARVVA IVSILFIVLA TMGLSLNTIP EIQFNHTRYE GPVNNTRLVW SMEDNPHLEV
VEAACIVWFT LEFVLRFWAS PDKCKFIKGP MNIIDLIAIV PYYISVILVH SMQAEDTGEY
SSLTSVRKIV QVFRILRILR VLKLARHSTG LKSLGYTLHQ SYKELGLLIL FVLLGVLLFS
SLAYFAEKDE PEPNDFRSIP ATFWWAAITM TTVGYGDIVP RTFLGKIIGS GCCICGVLVV
ALPIPIIVNN FAEFYTEQSR REKAQRRMEA MESAKRKGSL ISVSSFIQKR PSVDTGCSHD
KDFSEYSSDC SDSSGCSGRD VRNNMAYFKC RNNGGATVVQ QATSVDIEAA AAAVGRLLDE
ANSKAETKHH VGLCVDDSDD PNLQASPAPV AIAIPQLPRP RPPHPQLHPL KLAKLNSPGG
DSGDTFGTCS SNPQSPLTPS VAATAAIPAV VVPVSSVLPP SMTLEAGGGG AQTPKSRRRQ
DRIKFVEPAT EDGGRSYASS PSASPLLGSL GRFFSVGSGG GGGGKRRSVD ATESTDQTRR
LLQPRQHHQL LRPTLPGCHS SSTGVSPLTS PSQQRRSQQP TGILKRHLSA AKMSSIAESW
DTAGGSRLIR RRSIDEPSTT SPSSVACTSS SATRAVTAAV RTATKANDNR PEPATTADIK
KPPLISASTS PTECSASRTY RRGAAGGAHL AQVKPALVGC CCNGCCEEPV VNEATPETEA
DEATEGEAAT ARSCLRSRSQ KLHIRVDTAA RICGPQRTRL TVRPVRRGRS SRRSGRHRPV
VRATQAGHLG RVTKRICAAA DAADASLLQF ANQPGIVAKK LAKRTASPPA GQVALPQLLR
RHQPAAADGV ATSRQVALLL LNYPHLWLRE SLQLPDLGVL IHWQGAVRLQ LRLTAAIILL
LLLLLRRRRH QPVKLSAQHR CSRFYLRYDF EFNIISIQSV FVNSQLVIAS SHVGIQHARQ
VEQAPGFLHH VNRIPQGVGV IFAIQSRLEQ FPSDPIAVAQ QPLRVQTVRL QLALLLLGYA
AKAVELVQAL DSTVEDSHWM IVIGWNFTGS KSALSRSALG SPAAETDDEA EPATAAADSD
AERSRRGSTT EPALCTVEAA DVQCHDAILR AA
//
