ID   A0A1I8HJV6_9PLAT        Unreviewed;       804 AA.
AC   A0A1I8HJV6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Filamin-A {ECO:0000313|WBParaSite:maker-uti_cns_0006486-snap-gene-0.3-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0006486-snap-gene-0.3-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0006486-snap-gene-0.3-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the filamin family.
CC       {ECO:0000256|ARBA:ARBA00009238}.
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DR   AlphaFoldDB; A0A1I8HJV6; -.
DR   WBParaSite; maker-uti_cns_0006486-snap-gene-0.3-mRNA-1; maker-uti_cns_0006486-snap-gene-0.3-mRNA-1; maker-uti_cns_0006486-snap-gene-0.3.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   CDD; cd21311; CH_dFLNA-like_rpt1; 1.
DR   CDD; cd21230; CH_FLN_rpt2; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR044801; Filamin.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR001298; Filamin/ABP280_rpt.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR38537:SF18; FILAMIN-A; 1.
DR   PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00630; Filamin; 5.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00557; IG_FLMN; 3.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF81296; E set domains; 5.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 5.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          39..145
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          194..297
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   REPEAT          304..402
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          404..516
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          581..677
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          675..723
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REPEAT          727..804
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   REGION          167..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          522..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..577
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  89192 MW;  EE2F0DE63DEC4366 CRC64;
     MEGDYNYYDY DYDDGYIDED EEEMPATEKE LADDAQWKII QKNTFTRWAN EHLKQAGKQL
     ADLQYDLSDG LRLIALVEVL AGHKFRHVNK RPNFRTQKLE NVTMTLKFLE EEEGIRLVNI
     DSSDIVDCKL KLILGLIWTL ILHYSISMPM WEGEEELPQD DHDAVSAAAA VQDGRPDAAG
     GAAPGDPVPD GKGPSPRQRL LGWINSKMPD KPINNFTTDW NDGIAIGALV DACAPGLCPD
     WDVWDPKRPL ENCTEAMDAA EQWMEVPQLI RPEEMINPRV DEKAMMTYLS QFPNAKLKPG
     APLRPKTNPA RVRAYGPGLE PEGNTVGAPA RFTVETFSAG RGSVEIIVLN PRGQKEPCEV
     IFNNDRNLTY SCAYTPSMEG EYRVIIKFAN QEIPRSPYKV IVEGAAGDPS RVTASGPGIE
     PTGNQVAKRT FFNIFTADAF VEGKAARRVS GAGPGNVDCV ILDPHGQRDT IKPRVTHTGQ
     DDVYLVEYTP REEGLHSVNV FFAGQQIPGS PFGVDVAGRE MPQRMQPHQQ PQMQQPHMMQ
     QPQMQQPHMM QQPQSMPPEQ MPQQQRMQPQ HQRPQMQRPP SGDYFPDRVY VTGRGIQPKG
     VRVNDQADFY VHVENAGEGD CSVQIIGPGG GNEPCKVERT ADSVYTCLYV PRKAGRYTII
     VKFGPQEVPR SPFPGPSEAQ IQCSDNGDGS ADVVYYPTAL GEYAVHVLCN EQDIPRSPFM
     PVISERQPQL RPDQVRAQGP GIGVPEAVPL AVGQPAPFTL DTRNTNGPPE LVAAAVYNPR
     GDPIPLDMRQ QAPGLLQCSY VPQE
//