ID   A0A1I8HKD6_9PLAT        Unreviewed;      2279 AA.
AC   A0A1I8HKD6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0006624-snap-gene-0.2-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0006624-snap-gene-0.2-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0006624-snap-gene-0.2-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family. {ECO:0000256|ARBA:ARBA00010441, ECO:0000256|RuleBase:RU003750}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   WBParaSite; maker-uti_cns_0006624-snap-gene-0.2-mRNA-1; maker-uti_cns_0006624-snap-gene-0.2-mRNA-1; maker-uti_cns_0006624-snap-gene-0.2.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.1760; -; 1.
DR   InterPro; IPR000462; CDP-OH_P_trans.
DR   InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR   InterPro; IPR048254; CDP_ALCOHOL_P_TRANSF_CS.
DR   InterPro; IPR014472; CHOPT.
DR   PANTHER; PTHR10414:SF37; BB IN A BOXCAR, ISOFORM C; 1.
DR   PANTHER; PTHR10414; ETHANOLAMINEPHOSPHOTRANSFERASE; 1.
DR   Pfam; PF01066; CDP-OH_P_transf; 1.
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023209};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003750};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        777..799
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1303..1325
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1386..1408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1482..1501
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   2279 AA;  253397 MW;  79D7A28D248485C2 CRC64;
     LLVWLSAVNA LVENNAEGLQ RELVHRVDLI QIVQDEVQQR CSACSSSVPF ASLINLDLCN
     LGLCNLFFNF DGRSLVGLKI FHQGVVTQEI AFRSGETRQL ELFQIRPFLA HDGRQQLVLQ
     AIACHSELNG ASLLDGVSPK QRVQNWIDIL FDLLQQHCVT SGDSRLDLVH VALVAHWGSI
     ISGQRSALVR IVAFSIDMRS LGRPSLFHVA ICASSTSMEI GSMFSVVGTE FGRPLRNGSH
     ICSIRSIRYC FVKHPTKRRE TDTKASLGHS WNQSIDVQLT TAGNLRARTR SVVPTGLKHR
     ITFRVLRTFS MKNFQQFSRE VSDLTRCQEI VDEHKELLIG HLCIRHQEYH ADVLQTRLDV
     QLSEVCLEVW DAVALAEARR DSDCLPEPPT PTSRAFPRGD SRMRLMRRMC EIASSNSTRF
     IAALISFASS RILLMSSNFS TGMYFGLSDA GREMAVHVWR REHHCLVHLI FKSFFHDFLH
     NLLVRFDVGL LRQLVAVDAL RLVHVEADNR ERRVCNTAGH LLNWRWEALH LQMLRQDTVV
     DRAHRVLSGE GQRKDGEMTL QTRIDGETAS SRVHASDVLS VVDILQSQLC SVVPMAVVHV
     LPNQSVRLHR EVLVYLGHIQ IVDEVDQLLG ARRTKVSSSL LLQRLLQNAL QHLRGGVKVE
     RHVRDHVRLL GLHFARRQPR LDVRVPTQVG RVQVQNTGTG HGGRRQRNAL VRGQRQILLS
     SMTVFSDSIH MGSMSPSRTI HLGPSWVMLA RSRMITEKRP SFHSRVDGLM MPNSSSLVTA
     LGFKSTAIGF FFWFWYVLFR ARHTFDLPRC PARTRVSYSE KLLKLHDLQD EVVLWLELEI
     QCSSAHLLLE VQVALPRHVQ GGEQVTDETH EDGKIVGYNL WDVEVAQGSH QHLIFRPLRI
     ASLQGAGHHQ HRLDGPQTPI VVILLRQQLS AQRVNLLAEE VEAGLLVLDG ILDALHLNGH
     HGQHLYGDAV ELVKAAPGTR LRQALVNVSD RLVVHLFGAV EHVNHDAQGS AKIFRRLRLS
     STYFIEKRSA AHDEMQRLGQ CNVAAISERS DHKSRRVTQV LVSVAELRVA DVGKAVALDS
     SLFVLFIPTM AQLGQPGEGL RILYLLGNQF SYDISIVHVD GTDGHDFLSV LSRQLANQHL
     DQGVQLCDLL LVIVFQRVLV TLLKAGEGNV DLARPANLTA SQGHLRRIVE NPLVTRLFFL
     LPDVLRTNED RLKMGPGPLN LEPNLDYLIG RAQLLLPGVY FSGKTSISFL DELLQFIQCL
     CNAVDKMLLK HKRPTFDLVQ QRLLELRRIN PEPSLKHNSS LNFFNFFVYG LVVVDLLLEL
     LQRWLALRDA ILSVRINLLR CKDVAILEEL VLELFTILHP QVSIGVEAAL VLHGFLHDSL
     HPFHDLGAYS LQLIVVFHFL LVVLVPAVRS QTRNVGRLPV DVGGNAVHQL EEAIRLIFVK
     CRIEHNIGPL QLHEGHEQWR VALPVDCLLA QELQRAHNDV NLLSLLGDLI LALLETVFPI
     VQVEQGLCVL ADIVVPLHVM LRLMMCSLSV SFFEYRSSAA AGAVSCGLSS SGAVSERSFV
     SSSRTINGWL RFSEQLWSTP LTHSWKARFW NLQHSISKYQ ELLVLSLDKL SILAFDCSGI
     LGSRAVVERL AHDGGQAPVN VFNLLVEVIV VVHELLVQRV QDVVALVAKN LVVVVELLED
     VHSEFAEASA LHAAVFNLLE LEELDRRVHD VGYHGYALYK SVIARKDQGV GKVPLHWLAF
     LEVFFHFSPV LFECALEGVQ DCQGFLHSDH SLFDFAFEDF VRVKEVAALE FESLMNLLQQ
     DNDPGGHTVV LAVRPDEAQN MEHGADLLLA FVELSLFQVG KEVVQRLQMQ ADVLSFVQGR
     NHAAKHVFER RRVRAVDGLQ DVAHLLHFAA CQLRMKNTKM PSPSSPSRRF ITGPLNERQL
     RRLAQHKYNA CGSSLLEIVM QPLWRRLLCL VPMRAAPNAL TLTGLAFNAS SAGLMLWLCP
     DARQNPPAWL CLYAAVALFS YQTLDALDGK QARRTGTASP LGELFDHGCD AANTLLLCLC
     VCIAAGLGEE PHLLLFMIGA AQTVFYAAHW LGYNSGRLQF GFVDVTEAQA AAMAVFLATA
     FAGVGVWDLQ PAAGLPWLRV RHCLPVSTVL ASAPLVCRLT VSVATPGGLS VAGSGRLGPG
     LAWLALSLLS AAAAGAAVST GALHRHPCLL AFALGAPAVK TCQRLIIAQM TRSSIRTLDL
     CLVWPALLAV GIGVGHRWLG LTEGQVGWGV SVAAAADCAV YSGRVCRQIA AYLGVQIAC
//