ID A0A1I8HKQ9_9PLAT Unreviewed; 394 AA.
AC A0A1I8HKQ9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Carn_acyltransf domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0006539-snap-gene-0.1-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0006539-snap-gene-0.1-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0006539-snap-gene-0.1-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR AlphaFoldDB; A0A1I8HKQ9; -.
DR WBParaSite; maker-uti_cns_0006539-snap-gene-0.1-mRNA-1; maker-uti_cns_0006539-snap-gene-0.1-mRNA-1; maker-uti_cns_0006539-snap-gene-0.1.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF67; PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 39..374
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 351
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 394 AA; 44612 MW; 34CE3D4602BB8F89 CRC64;
LQNSDAMELD LYKTEAFPDL TRSSGVPTFS LEDSLPSYPV PKLSDTLDLY LSSTRPFLTD
SEFAATRDLA RQFELGIGRE LQARLEQRAA EQRNWLAEWW RHYAYLTNRT ALHPLLNMAG
VGPYHHQYWP ARDGSATERA AMMCRYYAVV WKSLREQTFP VDKNAAGKYM SMEQFRRYFS
SCQLPGRQAD TLASHFRPRS EGASPRHFLV LIRGRMFSLD LLDEAEQPYT VAQYYRQLDR
LVKTVESSAD SSEMGDASFS AGSAAGLYGL PRPDWFEARR HLGSLSPVNQ RNLDLVEQAI
FVLSLLLDER GCSNKRLLEL ALTGDIQSVV PDKSCNLMVT GDGVWLNNCG HTPMDGMTIA
LMTYYVEGQI YKTQVRLLAI VDVKMYSLDC ASCV
//
