ID A0A1I8HLW9_9PLAT Unreviewed; 468 AA.
AC A0A1I8HLW9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0006786-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0006786-snap-gene-0.3-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0008598-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR AlphaFoldDB; A0A1I8HLW9; -.
DR WBParaSite; maker-uti_cns_0006786-snap-gene-0.3-mRNA-1; maker-uti_cns_0006786-snap-gene-0.3-mRNA-1; maker-uti_cns_0006786-snap-gene-0.3.
DR WBParaSite; maker-uti_cns_0008598-snap-gene-0.2-mRNA-1; maker-uti_cns_0008598-snap-gene-0.2-mRNA-1; maker-uti_cns_0008598-snap-gene-0.2.
DR UniPathway; UPA00223; UER01007.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00145; ARGSUCLYASE.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
FT DOMAIN 18..347
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 413..465
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 468 AA; 49556 MW; 72E355374CBAAC34 CRC64;
MSVRAGAADT RIERDTFGEI AVPSWAYYGA QTARSLINFN IGRDADRMPV IRGLAYVKKA
AATVNGQHGL DPAVQSAICS AADEVISGQL DRHFPLVVWQ TGSGTQTNMN MNEVLSNRAI
ELLGGQIGSK TPVHPNDHVN MGQSSNDVFP TAMHVSVAME AAGRLLPSLK RLRDALAAKA
DEFQGVVKLG RTHLQDATPL TVGQEFGAFV YQLDCDLRRI DASLVDVHQL AIGGTAVGTG
LNSWPGFGED VAAALARLTG LPFRSAPNKF EALASHDALV ELSGSLNTTA CSLTKLANDF
RLLGSGPRCG LGELTLPENE PGSSIMPGKV NPTQCEALSM VACQVMGNHV AVTIGGSQGH
LQLNVYKPLI VRNVLHSMTL LADASVSFAD RCVSGTQVNA DRVAELMSQS LMLVTALNPH
IGYDKAAAIA KHAHANGLSL RQAALDLGLL SGDDFDRWVR PENMLGPA
//
