ID A0A1I8HNZ5_9PLAT Unreviewed; 3456 AA.
AC A0A1I8HNZ5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Amiloride-sensitive sodium channel {ECO:0000313|WBParaSite:maker-uti_cns_0007050-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007050-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0007050-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR WBParaSite; maker-uti_cns_0007050-snap-gene-0.2-mRNA-1; maker-uti_cns_0007050-snap-gene-0.2-mRNA-1; maker-uti_cns_0007050-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR Pfam; PF01734; Patatin; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 220..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1526..1562
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1906..2074
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 52..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1660..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2419..2495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2572..2595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2479..2495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3456 AA; 378497 MW; 74CBD21F7F053EBA CRC64;
TSTGPSAGWP VTCGKLFSRR TGTSSSSVKA VRSLKRFAGT LVERFRRNRL TTSAEVPEPS
LMRRTRASSR PTSGRSTSAA GHRSPWCLTR SRRCSALALI RVQQFIVDSS QVANVMSAPS
ESYWLPTNQR NRVVAYGVLV TRKLAWSQVR QSGCHDNHLA LSDCTDHQTR SVKRAEMQAD
QNSRVGQSER ARDILLRFCR NTSLRGIPRI VSADSRRYQI LWLVFVAALM IGCAINLQQI
INLYLAFDVV QMPSHVHRLD AQFPSITVCN QVPLSLQGRE TIYRHGWRAP RDYWAAVKQA
AKQLSRLKNI SREDWKQLSP YMAGFFSLNS YFSNIPAGHE PSDLGFTLNQ LMLKKYRDGS
SELPMSSPRC QAVGSWRQVH DQSRLNCYTF SVNTSYPVIE MEMLLYLGHE LSIGCDDCMT
IDPNTQIMGA RVVLHEQGSF PDVTKLGFNV YPGTLTEVRF TSVNWTRLPR PYGECHHRVP
PHLHIFGRNF AYSIDACKRL HHQEYIEREC GCTLASMLYS KGNASAMCER LDGDFNSFSL
RGLVQTTKRT RCGLLGSFRD VDYHCPLPCN YLTYEVSTTQ ALWPRDSMQL HLFESELLPL
LQHGPEYEFE DPNRSRNHSI LNNPARQAYA TVKQMYEDVV RAKGSSRTEA AKLVISNKLV
SRSLLTLRIS RKDFTVLQIV DKPVRTLAST LSQIGGLLSM WIGLTLVWLV EVLELLIKLA
VHWQSRLSNR RAASSNEEPA NARLKERKST SVRFAVICSF CLILTASGSS LFPVKRSPQP
PSPRLQSLGS IEEVAKYLGY LDRHVHSVPR PQFGKRSLGS SGEFRSAAEA ARYLSSLRRY
LNSMSRPRLN AFLDLPPLDI FVRSEAEKAA RRLIDTGITL KPQRAMAKRK HLPHSDLCLK
DLQESGRPQR PLGRGTSHAQ PLSLIQDGLS GFGVCILTNG RVLATHAQHT GRLSTVFQNE
VLAISSCAAE LCTKNTSGNI VFRSDSQTAL LALCHTTTAS RTDIRALAMT LTGYGCFARH
CFLRGDIRNE VSLFCEYDNE DAQHFVCQCP FFTREQLNHL GPNPSIDDVC RPENISRLVR
FLRATRRASF FPNEDNAAGP GYLLPWPYAS LSRTQCNVSR TNSCAYRAVR PTQTLSNIIS
LLSASSYQLE TEVEAQCQLG RDRSSTVSRS ISSLQDFIDE EVRKRTELDS LIEALSDSPF
FKTLDSKPLT AIAEALQTEG RQQGCGRFVH CDCFYQSDTG LDRLFVLSDS DTQPASGGGA
ATRFRTGGLR LLYSPSGLAR SLLSERQRQS ISQAVHSFPC SLHARMPPDG FWSISFASIA
NCLDAWPEAK RHLLLQLWSH INDTLLLVLV EWLGLEAGSF LETKFYEDLL SQEIDRLADE
VAATSGVNFA SMSFYERRPL YRRLAVRLLE EISGTASPSE GAEDHITIVY CSVAPDKEAL
DGFRAFLVLE GRLETTPTQA TLGVSQGSSS VLPGWVGLVP YFAQSRLPFL VRPAVDDADD
EDDAKRDGSG VVGGGGGGGG VVLVIISDAL MDEMFRLHRG DHLVRKGDPT ETVEIVVSGR
LRRDGSTEFT RGDCAGLIEG LMESSAVSTC WSGDIVAVRE SRAVSLPLSL ARAWVSNTRR
LNILDRLLGS MCEAQLDRQQ QRLTRLQRRK QTRLRVCRRD ASDNGFKENN DDDLGYAPDE
DEKPVAHVTA WLTRQRRRNR SRLVDPTRFN LNELLHHLQL CLDAAHGTDT AMVVSETDVE
RHFGRPADQL PDAALRNWLE DLELAFSVLV LVSTGPVTRW TRMVLGFLDC LVVCCDSNVA
GADASGEKDA TKMHLSRVHV AVFHPLTLRP VPEGTSLRFL RRRRWWARRV YHVRYSTGRY
KPKPEGSAAK PAAQSAAQQP ELASWISSHS DLARLTRCVT GVGVGLAFGS AVPRGLANFG
VLEALLSDGV AVDMIAGSGL GALTAAAWAL HEGDIGATRA GLQRHWARID SRWSRLRDLT
LPLVATYTGA ELNASLRQLF GDHRQAEDLW LPFVAVSTDL VVAQAVAHAT GTLWRSVRAS
CGLVGAYPPV WEPRTGRLLL DGAHTDRMPA RTLRRRLKAR YVVAAALESK RRLRPGTYLV
FGDAVSGFSE LLRSLNPFRL TPLAPSAADI QGALGSLASG ELSVGGKDDD DDLEDEEDAV
DAEVAEEASA APLSWCVTVQ PDPSFSTEEF AKAGGRAGDF ERWRGYWAAR RRLRRLGTLV
AQLNISCRDV PMDEAPQGQV FHSGGHLSGH VEHLSLAQGI VIVAAVFASR TSVGQELVKV
AVRRQLHGQA AGALAQRHTQ KSDQIGMGQA GQLLKLLGEF LLQGRICTAV QALDGHRLMG
NSCAVSNGVV HCRSSLTSET DFLVAASRIA LPLASPHGSS AAAAAAASAA AAALAEPRFG
GDFTRGGVLG KTGRAGGGCG GCEQGGRPQS SHSPAPDTKH QGGGGGGGVA ADPATPRDGP
ATGRLRHWLW SPRAPRARGS TVGRRDRSDY ARPVHDSPWH RWRCSSLGQL ACCVLTFEAA
EAANCNKQQP DNSRCSSSAS LLNWNIFDRT KTSRPPRNPL QTFGLKRWQK PVCTAPESPS
APSPPTSDGA SGLSLPSLRE GRLAEQRSMN FEPLPPFWPA AEYFHRVKET AVKAAGNAHL
NKTTAIAQAQ RLDSPTSAER AKMNKPKSRF LRKSIKQKEQ KRKTLQAIWP VSKLFKTELS
VRNPEQKWPY GLHFCTEFLA QQRNFSKFEN LSLNADQRRN LKVSRGINQK VSLIVLLRET
NLEVSELEIR TGGPRVTPTY DIGPPPLNLK PPRSHYSLIE ILNCDIVPVG MIFIFKAAQT
IKQRYESRLH HGDKERQEIG QYQVCRRGAL APKPDVLTVA AATASQGALH GLGANKGRAT
GSVRGAGVSQ QTVDITPSSR LTSPVGCLQR EQQHLLHRLW AVRLGADEMA CELESPTAHA
AIECRVGDSL DADVEGGAQQ TSVRRIDLLF ETKGSPGKPA AASQVLASVW NQTAEVDELL
TSREFGRLPV SASAKYCSLD VVRHAEHNGL LRVDHQADTR RNGNQPVQLP LGALDGRGQQ
GEVVGVAKHA EPLLRQMPRW SSSLVVPGFF GTATMCAVVH SLGAASPKST RFITLATSAA
TQGMRSASMG TSSGPSAFPP GDCWASLTTS AALTGATLKL SSAGSGVSGG SVRLSGSGGG
GALTMAAKNS RSSFLRSSGV SPARFSGLRR FRPRRCCVAS VKAAHRHGAE ELLRSVAGDD
LEVAVVTLQR VVNQCVNAAA SNNDFHSVGG SSAFYLEAVP ARKLASVIAP ALGADAGLYW
VQSRVERVVT RRVRVVHRVA LEAADAAGRV RGENCAWGWG ATVSTVSVGN VLWVKIGIEE
CPFCLSGVEN AEHFICDCPA FTLDRPQSKP EHFQRFRARE SLPARPLTKG YRASDYPPPG
FSGGGPRCPW SLGARGMGGN ASPLHPDAWN PLQLSQ
//
