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Database: UniProt
Entry: A0A1I8HQ72_9PLAT
LinkDB: A0A1I8HQ72_9PLAT
Original site: A0A1I8HQ72_9PLAT 
ID   A0A1I8HQ72_9PLAT        Unreviewed;      2598 AA.
AC   A0A1I8HQ72;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   28-FEB-2018, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|WBParaSite:maker-uti_cns_0007384-snap-gene-0.5-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Platyhelminthes; Rhabditophora; Macrostomorpha;
OC   Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007384-snap-gene-0.5-mRNA-1};
RN   [1] {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007384-snap-gene-0.5-mRNA-1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26392545; DOI=10.1073/pnas.1516718112;
RA   Wasik K., Gurtowski J., Zhou X., Ramos O.M., Delas M.J.,
RA   Battistoni G., El Demerdash O., Falciatori I., Vizoso D.B.,
RA   Smith A.D., Ladurner P., Scharer L., McCombie W.R., Hannon G.J.,
RA   Schatz M.;
RT   "Genome and transcriptome of the regeneration-competent flatworm,
RT   Macrostomum lignano.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:12462-12467(2015).
RN   [2] {ECO:0000313|WBParaSite:maker-uti_cns_0007384-snap-gene-0.5-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
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DR   WBParaSite; maker-uti_cns_0007384-snap-gene-0.5-mRNA-1; maker-uti_cns_0007384-snap-gene-0.5-mRNA-1; maker-uti_cns_0007384-snap-gene-0.5.
DR   Proteomes; UP000095280; Genome assembly.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 5.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095280};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095280};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2138   2160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2172   2190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2196   2213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2255   2283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2304   2326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2492   2515       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    361       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      367    423       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2598 AA;  292394 MW;  CEC10C1CD49907FE CRC64;
     MSDASGFLHI GDIISLYAEG GGGSTGFIST LGLVDDRCIV QPSEGDLYNP PKKFRDCLFQ
     ICPSFRYSAQ KQFWKAARNP ISSAPDAVLL EKLRQAAMME KQQNEKESSS ALGSVVQYGN
     VVQLLHLKSN KFLTVNKRLP ALVEKNSMRV MLDANGNEGS WFYIQPYYKL RSAGDQVIVG
     DKVTLCPVNA GQPLHASTYD LVDNPGCKEV NSVNCNTCWK MVLFMESREN KPEVLKSGDV
     VRLFHAEQEK FLTGDEYQKK SVVFLRKTLR TSATAATSSK ALWEVEVIQN DACRGGPGLW
     KSLFRFKHLA TGNYLAAELD EDDTPDPMRT KLRGDPSRSV CQLVFVPHGH DICSIFELDP
     TSVTRPDNLV PRSSFVRLKH LCTGTWVHAT GIPIDKGEDL PVMNKVGCAS LREDNEAFAI
     VQVSPQEVRD LDFATDSARY LNLLVRKLEK SGMAPNDRKF LTNLLGDIIF FLASQENNGG
     DPLMPYRHVC RLCYHLIKLS QESYRKNQEY IAKQFPFMQK QIGYGVLAED TITALLHSNR
     KLLEKHITDQ EINTFVALVR ENRESRFLDY LADLCVCNNE AIAVTQEHIC QCVLNDANKD
     ILINTELVKQ IEEDVSGDID TKTEKVVVML SFEKATRSGR EREQVMKSIE EIAQDAASGS
     KEDIQLLDYY KHQLDLFSKM CMSRQYIAIN FISPQLSIEL IHKCIKMRSL PFDLRASFCR
     LMLHLHVDRD PNEEIKPVKY ARLWSEIPNV LTVSEYSEMH TDQMENPLRE SIKPRFAKTL
     AYVERYLKDI ADSGWSSHDT GQNSLTYEIV SLARNLVYFG FYPFEDLLRL MKMLLAILDC
     IPIGAKSAAS AAGKKETSGA ETANGPQQQQ TQQHQGRGQG PKAIVTEENR QINRSRQEEN
     IVMETKQRIL EILHYILNVR LDYRITYLLS VFKSEFDTLY TGNDSDGFGL CYRNPTSQNL
     DVEAIAAQAE DMFCEGSDSG HALDLDGQGG RLFLRVLLYL IMHNHAQVVS GALQLLFRHF
     SQRQEVLQAF RQVQLLVSAS DVSTYKQIRT DLDEIRMLVE KSELWVYKSR NSGGGGGSSS
     RSARDDAASE LGSTTSHRTS AAAAAATPPA QPKPQPTKLQ PGQSAIDLDL GPEIDDNSRR
     NYVIMKEILQ RLASVCVAKQ PDGGVTNDKH QQRLLKNLGA NKFVMDLLQI PYDKKMDLRM
     KELFRLAHKF LQAFCYNNPA NQALLYKQLD SFLTNGINEA ETCTAIFRDN KRLCLEVPDR
     LIQHFVRAIE SQGRHVAYLQ FLQTLVRCDG QYIRRSQDLV MSELVSVGDE VLLFFNEGPA
     FEELLKLMCN ERSRTDVSGP LRYHIELVRL LASCTEGKNV YTEIKCHSLL PLDDLVKIVT
     HELCCPEVKD AYVHFLNHCY IDTEIEMKEI YTSAHMWTLF DNFLVDMALV CSSTHDRAHA
     DKALEHYVTE TVTSVVTTFF NSPYSEQSSS IEKQRSKQET FVRLLWSFYK VSQCDWLSGG
     RQRRVEKAIR ALFDIAKNRA VAIPVDLESL VSALMQKTDL VLKQAQTWLR SRKKSSAIGM
     MQRSAEQTNR DRTRVIVSKW QSVVQLLEQQ LKPLVKAEFS VLVDVLHNPE LLFAPDSEVR
     KNCERGGFIS RLIKHTEPLL EDKEENLCIK VMQTLREMML MNANYSEKGE MLRRNLLAFL
     DTEGASNLVV DIIIKRPKQR IFLEAVELGI ALLEGGNASV QASVLARLRE EDRSEKFVKL
     FHDLLSKAMA CVRISSSSLA SSAASSDVSK PARPDDRSGG AAFAASSDDP DAEHHRQRLL
     TELSPEFKTE LDDAALATSK AMHFIKHKIK NEDDRETTLF VGGKTNYNLV CQTLQFLDCI
     CGSTTGGLGL LGLYINESNV GLVNQALISL TEYCQGPCQW NQSSIAFHES NGIDIIIALI
     LNDISPLSEQ RMDLVLELKN NASKTLLAVM ESRYDSETAE RIMFTMAPVK QLVDIAKSAY
     YEDSFLDSKA QQQQQQEIRS DLADEIMNPR EVGHNIYILA HQLASHNREL AELLRPGGCS
     GDSFTDQALD YYARHTAQIE IVRADRSLEK IVFPIPEICE YLTEDTKWRV FHTAERDEQG
     SKVADLVGRI DQLHEEMVWQ RKLRRQPLLY RASCQMQLWS SVSFHLIVLM NLLIAVWYPF
     GPNSGVSNVG SLSGLSWLSV FLSLAVLLVW PRPACLRAFA LCVIMRLIFY FSVGPVLQLL
     GCLDIVNKLV FIVSLCGNRG LFNRPVRDLL LDGEFLYHVA YLLICLGGLC LHPFLYSVLL
     LDLVYREEML LNVIRSVTKN GKSILLTALL AVILIYLFSI VGYLFFQDDF LVEVDALEAA
     ADVSSSSGAP DDAAAAAASD ASGAAAAASA FNMAAATLKG LNKLSFGDNL IQGLAGSKLD
     SQQVNASNSS ASDSLAKNIS TLLLLSSTES AKTVESQKQP PESEGSGGKE RHCDSLIMCI
     VTTLNEGLRN GGGIGDLLRK PSMTESRFLL RVLYDLCFYF IVIIIVLNLI FGVIIDTFAD
     LRQEKQEKEE ILRNSCFICG LNRSSFENRE VSFEQHVQRD HNLWHYLYFV ILVRVKDHTE
     FTGPESYVSQ MMRARNLD
//
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