ID A0A1I8HQR3_9PLAT Unreviewed; 664 AA.
AC A0A1I8HQR3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Centaurin-gamma-1A {ECO:0000313|WBParaSite:maker-uti_cns_0007435-snap-gene-0.3-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007435-snap-gene-0.3-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0007435-snap-gene-0.3-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR AlphaFoldDB; A0A1I8HQR3; -.
DR WBParaSite; maker-uti_cns_0007435-snap-gene-0.3-mRNA-1; maker-uti_cns_0007435-snap-gene-0.3-mRNA-1; maker-uti_cns_0007435-snap-gene-0.3.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR PANTHER; PTHR45819:SF5; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 173..347
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 391..514
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 552..584
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 70067 MW; 922C7F167F2D0B3D CRC64;
MAACSTARRC QTPTTAAAVA GGAGRPSPSH HHQQQQQQQH RALLGAYNLP PPGQGHASAG
REYQHQVLLP ASLAAHQYYE PAAHSLPVQQ QASPQQLSSG KKTSDSTLWD HRPAAGDPGH
NTSMASGQPA YYSSVAGSAA VITASASCNQ PQQQPPLGMR GSRERASYAH GVSFVSSGYL
YKRSAGGALS RADWKKKYAA LAETGQLTYY SSLHDYMADS HGKTIDLRLT TVKVPGQTRP
TSNGLLLKTQ LSQQQQQSAQ SSQHPQRRRA KSSGRGGGGG IGDSAKTPDD DCSVGSSSAS
GTPAALGPPG SGFEFTIVSL DNRTWQFEAP SQAERDDWVR SIEQGILRQL QLLGRDGNPV
KNGAGASSAS NTSPLSSASG ATAAAATASA AASVQLLRDI LGNNVCADCG RPDPDWASIN
LGVLLCIECS GVHRNLGTHL SRVRSLNLDD WPANNVLVMR AIGNRLANSV WEACLDPASG
VYKPNADSPR ELKEQFIRAK YERREFLPEL PYPDCPIQQQ LVDAIARSDT RQVILCLAVA
GPAVNRAYSQ QDPRAAVHIA ATLGQLPYLQ LLLWYGADPA VRDAEGRTGH FYAAAAGKPD
CAEFLLLAGC PPTNLMSTSM ATATNNTAST AAATNSSVSS SSRRRSSRTA SPTSPTNATM
EIGL
//
