ID   A0A1I8HRM8_9PLAT        Unreviewed;       703 AA.
AC   A0A1I8HRM8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007588-snap-gene-0.4-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0007588-snap-gene-0.4-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC       2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR   AlphaFoldDB; A0A1I8HRM8; -.
DR   WBParaSite; maker-uti_cns_0007588-snap-gene-0.4-mRNA-1; maker-uti_cns_0007588-snap-gene-0.4-mRNA-1; maker-uti_cns_0007588-snap-gene-0.4.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616:SF304; SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE; 1.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 2.
DR   PRINTS; PR00176; NANEUSMPORT.
DR   SUPFAM; SSF161070; SNF-like; 1.
DR   PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR   PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Symport {ECO:0000256|RuleBase:RU003732};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003732};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT   TRANSMEM        158..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        455..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        507..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        579..603
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        618..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  77866 MW;  E69E0057E8153F2D CRC64;
     MAEKDRNDGD KPRNASNSAD TADEKLLKNS RGSAEEATDE SDGPATPVHP GYVAGAIYQS
     DEKVYNPEET QPFAVANQEL GPVAAAAAAA AMATSNSNAA DPQSNVEAGD LPVDAAQQGR
     AAWGGKVEFF LTAIGYAVGL GNVWRFPYLC YKNGGGAFLL PYCLMLALVG LPCFFLELSF
     GQFASLGPLT IWRCLFYLVH SFQARLPWES CDESWRSGLC REYRSPGESE NATEAISYGG
     AYWNFTGELE CSFNSTNVST KCRAPSEEFY ERYVLRLTSS IEDYGDFNWR LAIALFIAWI
     VVTLVLIKGI QSLGKVSYFT AIFPYLMLTA MLIRGATLPG ALQGVLFYVK PKWGRLLDYK
     VWMEAATQIF FSLSCCNGGL IAMSSYNKFR NNCQRDAVIV ALINCATSVF AGFVIFCNLG
     FMAHKKNVRV EDVAKGGPGL AFVVYPEALT HMPLSPLWAV LFFIMMATLG FGSQVNFRRT
     HRRPVLCAFQ DELRAMGVMG ASKKHAVIYR VIVCSFLFLL GLTMCFGGGM YLLNLVDNAV
     STFPLLVCCI VELVVLMYIY PYKQLAEDIR LMVGGKPNIY WRATWVVITP LVMVILIILM
     AVFNEPITYG TYKYSPPFQL LCVLIGLFII AWIPALAIYR YCREGGWILL REFLKPVEDW
     GPAKPKHRSQ FLNNLAQEST EGPAAFFQSK LSIAAEMQRA ASK
//