ID A0A1I8HU66_9PLAT Unreviewed; 612 AA.
AC A0A1I8HU66;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=IBB domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0007871-snap-gene-0.7-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0007871-snap-gene-0.7-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0007871-snap-gene-0.7-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394}.
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DR AlphaFoldDB; A0A1I8HU66; -.
DR WBParaSite; maker-uti_cns_0007871-snap-gene-0.7-mRNA-1; maker-uti_cns_0007871-snap-gene-0.7-mRNA-1; maker-uti_cns_0007871-snap-gene-0.7.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW ProRule:PRU00561}.
FT DOMAIN 21..85
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 214..259
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 64303 MW; B9A2C6434626532B CRC64;
ISPEDAEPDP AAAASSQPPS MAQPEEPAGL TEQQRSRMRA YKNAGLSSEE MRRRRDEVGA
QLRRQRHDEQ VFKRRSLLPQ PPAGEAAEAT AADASNAGSR MEECGGASDA GAVQDGARPG
SPMPSADGLA LLVGRLAEPS SEARLEATRR LRHLLCRVSD PPVDELLQAG ALPWLIAGLS
ESGHPALQFE SAWAITNVAS GQSRHSLAVA EAPGALAALV ALLDSWERQP AQLTEQAAWA
LANIAGDSAA TRDAVLAAGT IEPLARAVQH ASGDGLVRVG AWCLANLCRC SNGRHAGMAA
PQLAALQPCL PLLARLAFHG EPDILSDVCW ALAYVSDGDN DRVQAVIDTG VCRRLVALIQ
HPQQLVARPA LRAVGNLVTG DDIQTQVLLN CQLLPALSSL LSADGPDWAR KDACWVASNV
AAGNRSQIQA VLDCSLAGPV LEALRYAEFG TRKEAAWFVA NAASGGSPEQ VNYLVSCGCL
QPLCDLLNLP DARIVEVALT ALEAVLRSGA SLAAAAGSGP NPFVHLVEEC SGLERLEYLQ
SHENERLYRR SHLLIDRYFS ASADDEALDE ERGDADEQPL QLTTGSGGGV SGGDGSGGLA
VPAAFEFQEP PA
//
