ID A0A1I8HUS3_9PLAT Unreviewed; 271 AA.
AC A0A1I8HUS3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 03-MAY-2023, entry version 21.
DE SubName: Full=Neur_chan_LBD domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0008030-snap-gene-0.7-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0008030-snap-gene-0.7-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0008030-snap-gene-0.7-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR AlphaFoldDB; A0A1I8HUS3; -.
DR WBParaSite; maker-uti_cns_0008030-snap-gene-0.7-mRNA-1; maker-uti_cns_0008030-snap-gene-0.7-mRNA-1; maker-uti_cns_0008030-snap-gene-0.7.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF925; PROTON-GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 36..271
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022251332"
FT DOMAIN 75..258
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
SQ SEQUENCE 271 AA; 30771 MW; 7E500CD5CF19BA64 CRC64;
EKKLQVISVW LPPMSPLSSV VLLWLVFPLL HLVAALDPAT NADVPACRAL AAAAGSQTLP
SCHVILAPTL FGYQCNVSVM IEVKTVYGLD ESELLEWSGW VLVVWQDLRL AWNDSDGNVP
QLKMTRGQIW IPDVGFWNAK EIEFMDLRNA KFSDTTVFAN GTVSLYVHTV IRFPCQIDMY
LFPFDTQTCK LEFGGISSDL HFFNFTMESR MSSAKVDSTF YSVGEWHLER LDQTSSKYNA
AGQEFGYYSI EFHLRRKPLY YAVLILLPFE M
//
