ID   A0A1I8HYS7_9PLAT        Unreviewed;      1158 AA.
AC   A0A1I8HYS7;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Transmembrane protein {ECO:0000313|WBParaSite:maker-uti_cns_0008565-snap-gene-0.3-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0008565-snap-gene-0.3-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0008565-snap-gene-0.3-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A1I8HYS7; -.
DR   WBParaSite; maker-uti_cns_0008565-snap-gene-0.3-mRNA-1; maker-uti_cns_0008565-snap-gene-0.3-mRNA-1; maker-uti_cns_0008565-snap-gene-0.3.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616:SF279; SODIUM-DEPENDENT SEROTONIN TRANSPORTER; 1.
DR   PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR   Pfam; PF00209; SNF; 1.
DR   SUPFAM; SSF161070; SNF-like; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        18..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        158..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        270..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          328..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          470..585
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..442
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        516..585
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1158 AA;  125840 MW;  3F83F46B4E09F98E CRC64;
     MSATAASANP GFRWATSLWS FILALLSFSS ECLHTLVLAD VLNTWLSGRC VGCHQRLRSL
     LDRWWPLMML FSAVLALSSL PLFSAFAAYS ALLCWQPAWL SGILFLTAAI LTFLNLAICA
     DCLSAVAFTA TSGALRLCGG RPISFHDLLR VGGEGLRVWW LPAFCLGMAG LQLPLSTSAG
     FHLVELLDAY GIAWSVALLC LMELATVSWV FGVQQFSAII KIMLRGNLSL WWKVCWTVLS
     PAALIANLVI KWFKKPNEVG LPLPSWTINA SYVLEFLPLL PLPVCIVYYL VFTAKGSFSQ
     RLTALVAINK SMFNGEEFNK QVYGHRTTDD PIAESTAGPS AVTEGADERS AGATADDADG
     SGGGASSTPN GKINHRRLTS KRRVSIYGNE FAIRMDSTSS KMQFSRLSGQ QQPLSTVHSL
     ASTSSSARRA YNKSSSSAGS GSRKLDLKGM MAAQRNSAVL PLVSLAISGG GGGGGGSSVK
     NSESAGACGQ CRAQTSKPQQ KRLRSPLRRH WRTQAFRPAR HAETARHKRS SLEKGETDEV
     PSREDSDSHS VTRRCSRRQR LYSERWPRHT NQIQSRKPDS RKGCCKADTE SRLQYTMSGS
     ISRRLTKSSK ATQWQRLGAF RMYCTRPGWS ITTGSGCRHS SQCCFFDRPS QRVRQCRWRL
     PTVPWQAQRR RSGPDEAPSR QIRQTGVSCS ALPHRTAKLR HGVRLRRSLS SNAVSKNFGC
     ALRHRIALRH RCRWYRRLGR KLTDRGRLAH LVHVPVCVSA VIEPAREVGR TRTVRDCRRS
     PASVSREVSR QHRVADINAA VVRDSIGEQL LLQAGVPRVP DHQVSEHVAD AGSGSGYADR
     GSAGANVLGG LVDVATDGAR VQAGCRGGAA QKQRAGQREG AAGRADCKAL HGDWLAAAGG
     CGNGSGLKWD LLRTLNSLLE NSCCLRLGFL AYPITRFPNT LPMPAPDPAT PTVAAPAPMY
     LAAWSMSRRT ALECRLAAGA ARLRNSGRDS ARARLVVRTA RHCMATGWLL LGAAGTVRLW
     LLASYHARQL ASDPINFISG QLHLGVAFSG SLGQVFAQRR RRHSRLRRRR RPGQRGEQAI
     NKAASGIVQP IASGPANIQQ LGQLLGGLSC RLLCLSGQAL PVLQLAALNL LTVLQGSKLL
     SGLLSALLSI GGLPDHFR
//