ID   A0A1I8HYZ5_9PLAT        Unreviewed;      1007 AA.
AC   A0A1I8HYZ5;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=RNase H domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0008857-snap-gene-0.9-mRNA-1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0008857-snap-gene-0.9-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0008857-snap-gene-0.9-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A1I8HYZ5; -.
DR   WBParaSite; maker-uti_cns_0008857-snap-gene-0.9-mRNA-1; maker-uti_cns_0008857-snap-gene-0.9-mRNA-1; maker-uti_cns_0008857-snap-gene-0.9.
DR   Proteomes; UP000095280; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU000679}.
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1007 AA;  112087 MW;  6A785113D0040274 CRC64;
     DRPTKSKRQG PHQARSDLGS DFVDLTPDDQ SLADNGEDLL RSISPRPGSQ SSHSHEPSVA
     NDYASLVWAS GLSVKSNLDA LYKTQGRACR MTMGAPPSTP FEGMNAFLCA PPLDIYIKGE
     AAKSTRRLLD AGVAFKKVRA FKKRSLIPHS DLCLKALEEC GGLNILMDSI PATLLLSQRY
     KVTIQPRHEA SDSWSDSEVH CYTDGSMRHG LSGFGACVFF KGEVSEVLAI SSCAAELRRR
     QLSGRKFIFH SDSQAALRAL CRSTASSRPE SIPLLARYLK DTGRADLFPP PVRRTALQAR
     PTGPPERHHF DGSLWSPGAS GMGGLLRLLA ASAGRPLQLS QADSSVTRRM APPIKSGALA
     PVSGSRRNTE CTTVLAVNVA AGSGSDTSCT SCGQYDSARM MRFASWSYCR CKHFELFHAE
     TSGRSAQLAV MGVLRMLAET FVFNTSMRGF MKLYKTPHRF LRCLWALYAI SMLSLWITAC
     YFLIEHYSGF YVTVQQSERI QDITPLPSIT LCSQAPMGDH AASLWSNGTI MSPMHLHAAM
     KRSMRNAFGN GTSRRLSQFY AAKDVFYADK ISTYFQNIDI TEARRIGMRP EDLLVFCLMK
     HTPNNNPSVS HDEICRLSVK WVRHPLYLNC YTVTVDQEDT LDVSSVSLIL RSGVAQPLPL
     QGHVFDLFSQ SQGLKISLHE QGSHPNIDES AISVGMGRNT EIRYTLVQHR RLNLGNQRSN
     CLDSEKTAKQ RVLRDFDETY NYTFDACMSQ AIGQLILGEC NCVSAFHLVT QVPTRNTPFC
     HYHEGENTSS LLSRLDCVRN IKLPHRIAQL RTTTCLRRCN FNQFDMQVSS AQWMPTRWQL
     KLVLQLAPAW DIMIDHHSSE AEVAEARRRL MSFIDSPNEQ RQLLSNTSEP DISRLTLVTV
     SRATYNTILK TETLQVTLST LLAQIGGLGS VTIGLTITEQ RPTLVGRQRR RRRQFRVVES
     GGTNPQTPGV GVTYGFGCTC HPVLWIKYQD QLPLIIFSAI YAKLEPN
//