ID A0A1I8I2I5_9PLAT Unreviewed; 1362 AA.
AC A0A1I8I2I5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0009504-snap-gene-0.8-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0009504-snap-gene-0.8-mRNA-1, ECO:0000313|WBParaSite:maker-uti_cns_0012688-snap-gene-0.5-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR WBParaSite; maker-uti_cns_0009504-snap-gene-0.8-mRNA-1; maker-uti_cns_0009504-snap-gene-0.8-mRNA-1; maker-uti_cns_0009504-snap-gene-0.8.
DR WBParaSite; maker-uti_cns_0012688-snap-gene-0.5-mRNA-1; maker-uti_cns_0012688-snap-gene-0.5-mRNA-1; maker-uti_cns_0012688-snap-gene-0.5.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 608..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..147
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 158..262
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 384..478
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 701..939
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 857..930
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 970..1225
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1142..1216
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1231..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1362 AA; 153114 MW; 8140CAD48D772CB1 CRC64;
MHTISKTYLF GYFPNIQQIM LLGILIEFAL SVLSATSPAP SAKPVESVTL QQFANASQAS
LSLGCRLPGN SSDRVTYVEW QVHGDTVCRL FLQRKPMELD ECRSSLHSLG IGINDAGVQL
VLAPVLARHE GRYRCLAYED SDSYELVTNV LVRDKPFKPT RLQHVDVGRD WVRLGWEPPR
QQSHLPVDHY EAASWPDLDE PDSRKPPAGV TWQRVRDNNS FLHSHRFSYL SVYTSYCFAV
RAVNSIGAGQ PAVRCGIRTR GRPPERGAVS ARLVSANATR AAFVVAYQPD RLHGRLRQVE
LLCQLMRYRE LNVAFAPEDR QLSALGLRAL LPSRAFNDST ELVWLAEDLQ PYSQYRLIIK
AYNEEYDGPP EVTKFNTTEG LAPSPSLMQE TQLQFDTNAT LTWNQRRRIP GQLLYYRVRY
SPISYPAVQY QLNVSAQHNR VVLTKLQPMS EYRVSLAAVT GLGPGAESNT IVVSTEPSWP
SSPRQVQIET GFEAGAVVSW AHSRFTMQIP KSRKSSGIPL EAPARKYPAH LLAFRVLIPW
SQLAAGRSPP DDSGVLTRVS FSVRSVGLSQ WSAGRRYPGH VSEDCTTDIP AAYIFPKSAA
SHSTKQPVIV GVIVGGCIML LAIGIIAFLI WKWLCSHRGY RRPFGTAMET MEFVEHEYNG
TRSSGCRPQF RPYSQTEFKP LSIPDFREHV LASHANDNSA FQMEFDSVQQ STHRDWPALH
WKQPENLAKN RYTDIYPFDH SRGYHRPKAY IACQGPLPAT FDDFWLMVWE NKSSVVVMIS
NFVERGRRKC DQYWPGSGSQ TYGHISVRFI SQESKAAYCL RKFGIRDTRA KKSVKERLVH
HYLYSEWPDY GVPQYPLPVL NFVQKSIRSS DDHGPIVVHC SAGVGRTGTY ICIEAQIRQI
LQQKTVNVRG FLEHIRQQRM RLVQTEEQYV FIHDVLLEFL LCPEREVPRD QLTSYIKGLD
EPGPCGCSRL ETQYQLCVSE QPSPRDRMAA KKPCNARKNR CILPIDSRRV KLTAEPGVEG
SDYINASHLH GYFSMNEYIV TQHPLEETVF DFLKMIWDHN CSVVVSVYTE DSPDEPPLPS
IWPTPEDDMR EAEHLQLYFR NEEEYPFATR REFLMATKRD DYSLVVSLWT LKRWPELLGQ
AMDMMKLVGA VSERRAPPAA PLIVMDTYGS SHAGIFCALY SLYHQLQLEH SVDVYSLFKL
YHLQRPGMFN SSADLQFIYE VITFHASVNS PSSSLLPQRR DNGGTGGTLG SRGGDRREAQ
QLPAQEALHM SEQLKQLQQE VEETCGQEKQ LAESTVATAV PSGDAAITNG SDSGAAAASM
VAAGEPVSFG DVAIVNGSDG VEEARGAANA NGAVSLTLPK DA
//
