ID   A0A1I8I5K4_9PLAT        Unreviewed;       420 AA.
AC   A0A1I8I5K4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=inx {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=BOX15_Mlig012315g1 {ECO:0000313|EMBL:PAA66762.1},
GN   BOX15_Mlig012315g2 {ECO:0000313|EMBL:PAA54983.1};
OS   Macrostomum lignano.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX   NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0009937-snap-gene-0.13-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:maker-uti_cns_0009937-snap-gene-0.13-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:PAA54983.1, ECO:0000313|Proteomes:UP000215902}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DV1 {ECO:0000313|EMBL:PAA54983.1};
RC   TISSUE=Whole organism {ECO:0000313|EMBL:PAA54983.1};
RA   Berezikov E.;
RT   "A platform for efficient transgenesis in Macrostomum lignano, a flatworm
RT   model organism for stem cell research.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC       ECO:0000256|RuleBase:RU010713}.
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DR   EMBL; NIVC01002826; PAA54983.1; -; Genomic_DNA.
DR   EMBL; NIVC01001533; PAA66762.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1I8I5K4; -.
DR   STRING; 282301.A0A1I8I5K4; -.
DR   WBParaSite; maker-uti_cns_0009937-snap-gene-0.13-mRNA-1; maker-uti_cns_0009937-snap-gene-0.13-mRNA-1; maker-uti_cns_0009937-snap-gene-0.13.
DR   Proteomes; UP000095280; Unplaced.
DR   Proteomes; UP000215902; Unassembled WGS sequence.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF36; INNEXIN; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000215902};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        103..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        196..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        287..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
SQ   SEQUENCE   420 AA;  48391 MW;  8090420B32C802E9 CRC64;
     MDGYLSSFTK LAGAAKSVPH GAEDYYDRLN YALTPGILLA IATIIGMKQY VFEPIQCWTL
     KELDDQRMQY AENYCWVENT FYFDPDVPIG HTNKPGEGRT IYYYQWVPFI LMAQAVLFYV
     PHLLWLMLST NVGVDMRQLA EQARKLESDC LVGDERKTKV AFLASSLLRF FRYRSRYGHE
     NACKRLTSFL LGKPAFAMYL LAAYVLVKAC YIANCIGQLY LMRSYLGLNM TSFGLQIFND
     IANNRTWQTT NVFPRVTYCH FEVRNVGAPR SYILQCVLPV NMLNEKFYVV IWFWVVIMLS
     LNIVSLTRWL MKLMVSPSRR RIVKKYLKIA EVIDSDGKKF SRNKAWECEF VDDLIRSDGT
     FLLSVINKNA GDIVTAEVVR KTFELWHSQS TELDSPAESA KYITDEKMPL DPSAPKAVIV
//