ID A0A1I8I7B0_9PLAT Unreviewed; 343 AA.
AC A0A1I8I7B0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Pept_C1 domain-containing protein {ECO:0000313|WBParaSite:maker-uti_cns_0010168-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0010168-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0010168-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR AlphaFoldDB; A0A1I8I7B0; -.
DR WBParaSite; maker-uti_cns_0010168-snap-gene-0.2-mRNA-1; maker-uti_cns_0010168-snap-gene-0.2-mRNA-1; maker-uti_cns_0010168-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR012599; Propeptide_C1A.
DR PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR Pfam; PF08127; Propeptide_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..343
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018694639"
FT DOMAIN 89..340
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 343 AA; 37228 MW; 98FBD372154E5A10 CRC64;
MLKVFAVLLL AAASSAYPRE ESTAVKPMHE PLTQELIDYV NKVGTTWQAG RTSRFDSVSD
VRRVLGVIAN PNKPDIPVLS YPGSDIGDLP TEFDARTQWP KCPTIQEVRD QSNCGSCWAF
GAVEAMSDRH CIHSGGKVQV HLSAEDLLAC CGFSCGMGCN GGFLESAWQY WKKSGIVTGG
QYGTKQGCQP YSLPHCDHHT TGKYQPCSGD SKTPKCKRDC ISGYNMTYNN DKHFGASVYT
VSSKQDDIAK EIMTNGPVEA AFTVYADFPS YKSGVYQHTT GGELGGHAVK ILGWGVENGR
GAPYWLVANS WNPDWGLDGF FKILRGKNEC GIEGSIVAGI PKA
//
