ID A0A1I8I999_9PLAT Unreviewed; 1291 AA.
AC A0A1I8I999;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Solute carrier organic anion transporter family member {ECO:0000313|WBParaSite:maker-uti_cns_0010821-snap-gene-0.2-mRNA-1};
OS Macrostomum lignano.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Macrostomorpha; Macrostomida; Macrostomidae; Macrostomum.
OX NCBI_TaxID=282301 {ECO:0000313|Proteomes:UP000095280, ECO:0000313|WBParaSite:maker-uti_cns_0010821-snap-gene-0.2-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-uti_cns_0010821-snap-gene-0.2-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657}.
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DR WBParaSite; maker-uti_cns_0010821-snap-gene-0.2-mRNA-1; maker-uti_cns_0010821-snap-gene-0.2-mRNA-1; maker-uti_cns_0010821-snap-gene-0.2.
DR Proteomes; UP000095280; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF100; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1; 1.
DR Pfam; PF07648; Kazal_2; 2.
DR Pfam; PF03137; OATP; 3.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS51465; KAZAL_2; 2.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 766..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 794..814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..874
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 886..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1027
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1039..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1167..1187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1251..1279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..644
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 451..506
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 1080..1138
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 140885 MW; 75446948B9879DC5 CRC64;
MNNRKANSGQ KVEQNYESKM SPVVSEVEEN EEFKDNPDEV ACNWHPKCQP QCCQCFARPS
CLLLWLCLSS FTQGLVVNGF VNSVLTTLEL RYDMTSSESG LIASMYDIGS VLCLVPVTYI
GHRYRRSRLI SIGLLIMSVG SFVFTIPQFT TDAYNYQSPV SPLCYLSGKV YPDFCTKQTL
NNYKFVFWLG QFLHGVGASP LYTLAVAYLD DNLTVQQSGA FLGAYYMMSL IGPAMGYLLG
GIFLNIYVEL GVTPSDLTPS NTSLWVGAWW VGFLISGTLS LIIVVPLFGF PKLFPGSARI
QHEKKQETHG NSEAKCAEMQ ELNVKDFCPS VGVILSNPVF VFISFSGAAD AILVAGLSTF
GPKVLQTLFM VSASTATFTI GLVSVPSAAI GLLVGGLVIR FSNLPVRSLL WMCVGVAAVD
VLFGLGLLAK CDLQKFAGVN QNYPLTPNQS NSLNATCNMN CHCQESKFMY SPVCGADSVI
YYSPCYAGCQ SNATMINGAK YYANCTCITG QITANNYNFS AMEGTCKDAS CNKMPIVLVT
IGFFLFGIFF ISIPTLQCTM RVIPARLKDF GLGLQWVILR LFGSIPGPLV LGKLIDTTCS
LWTGGCGHQG SCSFYNGESF WAMVLGFAAV LKALEILFLI LAAALYVPPD QVIQVDVEIE
TKPDATPSQV QEVEEPKQVA AKSSPKTDDV LKSDSNELND DPDEVACNWH PKCQPQCCQC
FARPSCLLLW LCLSSFTQGL VVNGFVNSVL TTLELRYDMT SSESGLIASM YDIGSVLCLV
PVTYIGHRYR RSRLISIGLL TMSVGSFVFT IPQFTTDAYN YQSPVSPLCY LSGKVYPDFC
TKQTLNNYKF VFWLGQFLHG VGASPLYTLA VAYLDDNLTV QQSGAFLGAY YMMSLIGPAM
GYLLGGIFLN IYVELGVTPS DISPKNNNLW TQSRHESPRD IVGAENAATQ ISAKHFWSSI
VTLLKNATFV FLSFSGAMQY VIMTGLSTFG PKILQILFYL TKSSSTITMG LVTVPAAAFG
VMTGGLLIRF TKFSVQRLLW LSFIVACVDL ILGLGLLAKC NPQKFAGVNQ NYPLTPNQSN
SLNATCNMNC HCQESKFMYS PVCGADSVIY YSPCYAGCQS NGTMINGAKY YADCTCITGQ
IAIDGSDQKF SAVEGACIKN ACHKLQILLS MLFLFIFVLF STSVPILHCT MRVIPATLKD
FGLGLQWVIL RLFGSIPGPP LMGKLIDTTC SLWTGGCGHQ GSCSFYNGES FWLIVIAFAG
VLKVLEVALM GLAAFFYYAP PDEPETYSSV I
//
